药学学报, 2019, 54(9): 1531-1537
引用本文:
单天姣, 孙健, 梁海海. 细胞衰老与器官纤维化研究进展[J]. 药学学报, 2019, 54(9): 1531-1537.
SHAN Tian-jiao, SUN Jian, LIANG Hai-hai. Progress in the study of association between cellular senescence and organ fibrosis[J]. Acta Pharmaceutica Sinica, 2019, 54(9): 1531-1537.

细胞衰老与器官纤维化研究进展
单天姣, 孙健, 梁海海
哈尔滨医科大学药学院药理学教研室, 省部共建生物医药重点实验室培育基地, 心血管药物研究教育部重点实验室, 黑龙江 哈尔滨 150081
摘要:
器官纤维化是一种由组织器官为修复自身受损部位,过度分泌细胞外基质蛋白并形成永久性瘢痕,最终引发器官形变及功能衰竭的进行性疾病。细胞衰老意味着细胞周期进入稳定停滞状态,衰老细胞虽然依然具有代谢能力,但无法继续增殖,其通过分泌炎性因子等方式促进细胞外基质蛋白过度分泌,参与心肌纤维化、肺纤维化等多种纤维化疾病的发生发展。越来越多的研究表明,器官纤维化疾病发病率和衰老细胞数量均随年龄增长而增加。本文主要总结了在各器官纤维化进程中,细胞发生衰老的机制、衰老细胞对纤维化进程产生的影响以及目前针对细胞衰老的抗纤维化药物治疗研究进展。这些内容对于揭示纤维化疾病的发病机制及探寻新的抗纤维化治疗策略具有重要意义。
关键词:    细胞衰老      心肌纤维化      肺纤维化      作用机制      药物治疗     
Progress in the study of association between cellular senescence and organ fibrosis
SHAN Tian-jiao, SUN Jian, LIANG Hai-hai
Department of Pharmacology(State-Province Key Laboratory of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China
Abstract:
Deformation or failure of organs is the final stage involving fibrosis, caused by fibrous scars composed of excess extracellular matrix proteins. Cellular senescence means a stable stagnation state with no proliferation, during which the senescent cells maintain biochemical metabolism but promote excessive expression of extracellular matrix proteins due to secreting inflammatory factors, which contribute to the development of various organ fibrosis including myocardial fibrosis, and pulmonary fibrosis. It has been shown that both the incidence of organ fibrosis and the number of senescent cells increase with age. This review mainly summarizes mechanisms of cellular senescence and its contribution to the process of various organ fibrosis. Current anti-fibrotic drug therapy focused on cellular senescence is discussed. Cellular senescence has profound implications in the pathogenesis of fibrotic diseases and provides a new target for new effective treatments.
Key words:    cellular senescence    myocardial fibrosis    pulmonary fibrosis    mechanism    medication   
收稿日期: 2019-01-03
DOI: 10.16438/j.0513-4870.2019-0017
基金项目: 国家自然科学基金资助项目(31671187).
通讯作者: 梁海海,Tel:86-451-86671354,E-mail:lianghaihai@ems.hrbmu.edu.cn
Email: lianghaihai@ems.hrbmu.edu.cn
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