药学学报, 2019, 54(9): 1564-1573
引用本文:
唐于平, 尚尔鑫, 陈艳琰, 乐世俊, 史旭芹, 董婷霞, 詹华强, 段金廒. 药对配伍效应与功效物质现代研究方法与策略[J]. 药学学报, 2019, 54(9): 1564-1573.
TANG Yu-ping, SHANG Er-xin, CHEN Yan-yan, YUE Shi-jun, SHI Xu-qin, DONG T. X. Tina, TSIM W. K. Karl, DUAN Jin-ao. Modern research approaches and strategies for compatibility effects and efficacy components of herbal pairs[J]. Acta Pharmaceutica Sinica, 2019, 54(9): 1564-1573.

药对配伍效应与功效物质现代研究方法与策略
唐于平1, 尚尔鑫2, 陈艳琰1, 乐世俊1, 史旭芹2, 董婷霞3, 詹华强3, 段金廒2
1. 陕西中医药大学, 陕西省中医药管理局中药配伍重点研究室/秦药特色资源研究与开发国家重点实验室(培育)/陕西省中药基础与新药研究重点实验室/陕西省中药资源产业化协同创新中心, 陕西 西安 712046;
2. 南京中医药大学, 江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心/江苏省方剂高技术研究重点实验室, 江苏 南京 210023;
3. 香港科技大学, 生命科学部暨中药研发中心, 中国 香港 999077
摘要:
药对是历代中医药学家在长期遣方用药过程中积累起来的简约而精妙的经验总结,其尽管只是两药相合,却搭配巧妙、比例得当,能很好地诠释中药"合群妙用"的特点;药对是单味中药与若干方剂之间的桥梁,是许多方剂隐含的规律性特征与辨证施治内涵体现。本研究团队长期以来围绕药物相互作用的复杂性与中药组成成分的多样性,采用现代科学技术知识与方法开展了药对的系统研究,形成了药对配伍效应与功效物质现代研究的一系列方法与策略,本文通过重点阐述这些方法的原理与应用特点,为阐明药对配伍规律的科学内涵及优化组方的应用提供重要支撑,也为其他药对的现代研究提供探索性思路与方法。
关键词:    药对      配伍效应      功效物质      药物相互作用      现代研究     
Modern research approaches and strategies for compatibility effects and efficacy components of herbal pairs
TANG Yu-ping1, SHANG Er-xin2, CHEN Yan-yan1, YUE Shi-jun1, SHI Xu-qin2, DONG T. X. Tina3, TSIM W. K. Karl3, DUAN Jin-ao2
1. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources(Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, China;
2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine/Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China;
3. Division of Life Science and Centre for Chinese Medicine, the Hongkong University of Science and Technology, Hongkong 999077, China
Abstract:
The herb pair is the simple and exquisite experience summary accumulated by generations of traditional Chinese medicine (TCM) experts in the process of long-term herbal prescription for curing diseases. Although it is only a combination of two herbs, it is cleverly matched and properly proportioned, which can well interpret TCM characteristics of "great combination and artful application". Moreover, the herb pair is an intermediate point between single herb and several TCM formulae, which implicates certain regularity and some connotation of many TCM formulae for diagnosis and treatment based on an overall analysis of the illness and the patient's condition. Our team has long been focusing on the complexity of drug interactions and the diversity of TCM components to carry out systematic research on herb pair by using modern scientific and technological knowledge and approaches. As results, a series of modern research approaches and strategies formed for the compatibility effect and bio-active components of the herb pair. By representing the principles and application characteristics of these approaches, this paper provides important support for elucidating scientific connotation of compatibility regularity of herb pairs and application of formulae optimization, as well as explorative ideas and approaches for modern research on other herb pairs.
Key words:    herb pair    compatibility effect    efficacy component    drug interaction    modern research   
收稿日期: 2019-05-28
DOI: 10.16438/j.0513-4870.2019-0413
基金项目: 国家自然科学基金资助项目(81773882,81573714,81603257);陕西省重点研发计划项目(2019ZDLSF04-05,2019SF-300);陕西中医药大学学科创新团队项目(2019-YL10).
通讯作者: 唐于平,Tel/Fax:86-29-38184350,E-mail:yupingtang@sntcm.edu.cn
Email: yupingtang@sntcm.edu.cn
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