药学学报, 2019, 54(9): 1620-1626
引用本文:
肖春荣, 涂林锋, 张睿增, 刘定平, 罗永明. 山香圆叶黄酮类化合物的研究[J]. 药学学报, 2019, 54(9): 1620-1626.
XIAO Chun-rong, TU Lin-feng, ZHANG Rui-zeng, LIU Ding-ping, LUO Yong-ming. Study on chemical constituents of flavonoids in Turpinia arguta[J]. Acta Pharmaceutica Sinica, 2019, 54(9): 1620-1626.

山香圆叶黄酮类化合物的研究
肖春荣, 涂林锋, 张睿增, 刘定平, 罗永明
江西中医药大学药学院, 江西 南昌 330004
摘要:
通过大孔树脂柱色谱、聚酰胺柱色谱、硅胶柱色谱、ODS柱色谱和制备液相等技术对山香圆叶乙醇提取物的正丁醇部位进行分离纯化,并应用核磁共振以及质谱等波谱技术进行化合物结构鉴定。从山香圆叶中分离鉴定了15个黄酮类化合物,分别为:argutoside F(1)、木犀草素-7-O-[α-L-吡喃鼠李糖基-(1→6)-α-L-吡喃鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷(2)、女贞苷(3)、刺槐素-7-O-[α-L-吡喃鼠李糖基-(1→6)-α-L-吡喃鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷(4)、芹菜素(5)、槲皮素(6)、槲皮素-3-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(7)、野漆树苷(8)、木犀草素-7-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷(9)、刺槐素-7-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷(10)、木犀草素-7-O-β-D-吡喃葡萄糖苷(11)、木犀草素(12)、neodiosmin(13)、芹菜素-7-O-芸香糖苷(14)和槲皮素-3-O-α-L-吡喃阿拉伯糖苷(15)。其中化合物1为新化合物,化合物2、7、9、13~15为首次从该植物中获得。
关键词:    山香圆叶      化学成分      黄酮类     
Study on chemical constituents of flavonoids in Turpinia arguta
XIAO Chun-rong, TU Lin-feng, ZHANG Rui-zeng, LIU Ding-ping, LUO Yong-ming
School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Abstract:
Fifteen flavonoids were isolated and identified by macroporous resin column chromatography, polyamide column chromatography, silica gel column chromatography, ODS column chromatography and preparative liquid chromatography from the ethanol extract Turpinia arguta. Their structures of these flavonoids were identified by NMR and mass spectrometry as argutoside F (1), luteolin-7-O-α-L-rhamanopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), nuezhenoside (3), acacetin-7-O-α-L-rhamnopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (4), apigenin (5), quercetin (6), quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (7), rhoifolin (8), luteolin-7-O-α-L-rhamanopyranosyl-(1→2)-β-D-glucopyranoside (9), acacetin-7-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (10), luteolin-7-O-β-D-glucopyranoside (11), luteolin (12), neodiosmin (13), apigenin-7-O-rutinoside (14), and quercetin-3-O-α-L-arabinopyranoside (15). Compound 1 is new, whereas compound 2, 7, 9, 13-15 were obtained from this plant for the first time.
Key words:    Turpinia arguta    chemical constituents    flavonoids   
收稿日期: 2019-05-07
DOI: 10.16438/j.0513-4870.2019-0359
基金项目: 江西省“赣鄱英才555工程”项目(52513028);江西中医药大学“道地药材及特色中药资源研究”专项(5151300115).
通讯作者: 罗永明,Tel:86-791-87118850,E-mail:loym999@163.com
Email: loym999@163.com
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参考文献:
[1] Editorial Committee of Flora of China,Chinese Academy of Science. Flora of China (中国植物志(第46卷))[M]. Beijing:Science Press, 1981:27-37.
[2] Zhang WG, Zhou GP, Yang XJ, et al. Determination of nuezhenide and apigenin 7-O-neohesperidoside in Shanxiangyuan tablets by HPLC[J]. Chin J Pharm Anal (药物分析杂志), 2009, 29:912-914.
[3] Huang ZY. Preliminary report of Shanxiangyuan tablet in the treatment of pharyngitis and other disease[J]. (中草药), 1978, (3):36-38.
[4] Yang YF, Wu ZR. Study on the antimicrobial activities of different processing products of Shanxiangyua[J]. China J Chin Mater Med (中国中药杂志), 1986, 11:30-32.
[5] Zhan YF, Zhang JJ, Chen JT, et al. Studies on the analgesia effect of Shanxiangyuan baccal tablet[J]. Lishizhen Med Mater Med Res (时珍国医国药), 2005, 16:389-390.
[6] Ma SG, Yuan SP, Liu YB, et al. 3-Hydroxy-3-methylglutaryl flavone glycosides from the leaves of Turpinia Arguta[J]. Fitoterapia, 2018, 124:80-85.
[7] Ma SG, Yuan SP, Hou Q, et al. Flavonoid glycosides from leaves of Turpinia arguta and their anti-inflammatory activity[J]. China J Chin Mater Med (中国中药杂志), 2013, 38:1747-1750.
[8] Li JS, Zhao YY, Wang B, et al. Separation and identification of the flavonoids from Buddleia officinalis Maxim[J]. Acta Pharm Sin (药学学报), 1996, 31:849-854.
[9] Li YQ. Studies on the Chemical Constituents of Capparis himalayensis and Turpinia arguta (爪瓣山柑及锐尖山香圆叶化学成分的研究)[D]. Beijing:Peking Union Medical College & Chinese Academy Medical Sciences, 2007.
[10] Zhang WG, Zhou GP, Xie EL, et al. Study of the flavonoids from leaves of Turpinia arguta[J]. China J Chin Mater Med (中国中药杂志), 2009, 34:1603-1604.
[11] Cheng YX, Zhou J, Tan NH. The chemical constituents of Parakmeria yunnanensis[J]. Acta Bot Yunnan (云南植物研究), 2001, 23:335-356
[12] Tian Y, Tang HF, Wang XJ, et al. Studies on antibacterial constituents of Discocleidion rufescens (2)[J]. China J Chin Mater Med (中国中药杂志), 2009, 34:1377-1380.
[13] Jose ADR, Obdulio B, Julian C, et al. Neodiosmin, a flavone glycoside of Citrus aurantium[J]. Phytochemistry, 1992, 31:712-724.
[14] Tian Y, Liu X, Dong J. Apigenin glycosides from Euphorbia humifusa wild.[J]. Acta Pharm Sin (药学学报), 2009, 44:496-499.
[15] Shi S, Zou H, Zhang Y, et al. Chemical constituents from Neo-Taraxacum siphonathum[J]. China J Chin Mater Med (中国中药杂志), 2009, 34:1002-1004.