药学学报, 2019, 54(11): 1888-1894
刘昕彦, 邵瑞, 贺爽, 朱彦. 类器官和立体细胞模型在中药心脏毒性评价中的应用前景[J]. 药学学报, 2019, 54(11): 1888-1894.
LIU Xin-yan, SHAO Rui, HE Shuang, ZHU Yan. Application prospect of organoids and 3D-cell models in evaluation of cardiotoxicity of traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2019, 54(11): 1888-1894.

刘昕彦1,2, 邵瑞1,2, 贺爽1,2, 朱彦1,2
1. 天津中医药大学, 天津市现代中药重点实验室, 天津 300193;
2. 天津国际生物医药联合研究院中药新药研发中心, 天津 300457
关键词:    中药      心脏毒性      二维细胞      三维细胞      类器官      毒性评价技术     
Application prospect of organoids and 3D-cell models in evaluation of cardiotoxicity of traditional Chinese medicine
LIU Xin-yan1,2, SHAO Rui1,2, HE Shuang1,2, ZHU Yan1,2
1. Tianjin Modern Chinese Medicine Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
2. Tianjin International Biomedical Research Institute, Chinese Medicine New Drug Research and Development Center, Tianjin 300457, China
Cardiotoxicity is one of the main causes of failure in new drug development or drug withdrawal from the market. However, current methods for evaluation of drug cardiotoxicity suffer the shortcomings such as low clinical relevance, low reproducibility and lack of high throughput screening capacity. Therefore, there is an urgent need for establishing more accurate and reliable methods for cardiotoxicity evaluation of drugs. As a new generation of drug cardiotoxicity evaluation, cardiac organs in culture retain the biological characteristics and functions of heart cells in the body, and can realistically and accurately respond to the effects of drugs. This article reviews recent progress of in vitro culture of cardiac organs and 3D-cell models, with focuses on application and development potential of cardiac organs for evaluation of cardiotoxicity of traditional Chinese medicine. The advantage and future prospective of such cell- and organ-based models for unique challenges in evaluation of cardiotoxicity of traditional Chinese medicine have been discussed.
Key words:    traditional Chinese medicine    cardiotoxicity    two-dimensional cell    three-dimensional cell    organoid    toxicity evaluation technology   
收稿日期: 2019-02-14
DOI: 10.16438/j.0513-4870.2019-0105
基金项目: 国家重点研发计划项目(2018YFC1704500);国家科技重大专项(2018ZX01031301);国家自然科学基金资助项目(81873037).
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贺爽  在本刊中的所有文章
朱彦  在本刊中的所有文章

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