药学学报, 2019, 54(12): 2204-2208
引用本文:
任思宇, 王真真, 陈乃宏. 人参皂苷抗抑郁作用研究进展[J]. 药学学报, 2019, 54(12): 2204-2208.
REN Si-yu, WANG Zhen-zhen, CHEN Nai-hong. Research progress on anti-depression effects of ginsenosides[J]. Acta Pharmaceutica Sinica, 2019, 54(12): 2204-2208.

人参皂苷抗抑郁作用研究进展
任思宇1,2, 王真真2, 陈乃宏1,2
1. 湖南中医药大学药学院, 湖南省中药饮片标准化及功能工程技术研究中心, 湖南 长沙 410208;
2. 中国医学科学院药物研究所, 神经科学中心, 北京 100050
摘要:
人参为常用补益中药,自古以来被誉为中国的"百草之王"。在慢性不可预知应激、皮质酮诱导、脂多糖诱导等动物抑郁模型中,发现人参提取物中的人参总皂苷以及人参皂苷单体或苷元,均表现出显著的抗抑郁效应。本文以人参皂苷为中心,从当前与抑郁症发病相关的调节下丘脑-垂体-肾上腺轴、单胺神经递质和神经可塑性等多种假说为出发点,对人参皂苷抗抑郁作用机制进行了综述。总结了人参皂苷抗抑郁的机制、靶点及药效学物质基础,为从中药及天然产物的角度,多靶点、多层次地开发抗抑郁新药,提高抑郁症诊治水平提供参考价值。
关键词:    人参      抑郁      人参皂苷      人参皂苷Rg1      抗抑郁机制     
Research progress on anti-depression effects of ginsenosides
REN Si-yu1,2, WANG Zhen-zhen2, CHEN Nai-hong1,2
1. College of Pharmacy, Hunan University of Chinese Medicine, Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha 410208, China;
2. Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100050, China
Abstract:
Ginseng is a traditional Chinese medicine known as the "king of herbs" since ancient time in China. It was found in animal experiments that total saponins, ginsenoside monomers or glycosides from ginseng extraction all showed antidepressant effects in chronic unpredictable stress, corticosterone or lipopolysaccharide induced depression models. Taking ginsenosides as the focus, we reviewed the antidepressive mechanisms from the perspectives of various hypotheses, such as regulations of hypothalamic-pituitary-adrenal axis, monoamine neurotransmitter and neuroplasticity related to the pathogenesis of depression. The mechanism, target and pharmacodynamic targets of ginsenosides for anti-depression were summarized, in order to provide references for multi-targets and multi-level development of new anti-depression drugs, and improvement of diagnosis and treatment of depression from the perspective of traditional Chinese medicine and natural products.
Key words:    ginseng    depression    ginsenoside    ginsenoside Rg1    antidepressive mechanism   
收稿日期: 2019-04-11
DOI: 10.16438/j.0513-4870.2019-0264
基金项目: 国家自然科学基金资助项目(81573636,81773924,81730096);国家中医药管理局科研项目(ZYBZH-Y-HUN-24).
通讯作者: 陈乃宏,Tel/Fax:86-10-63165177,E-mail:chennh@imm.ac.cn
Email: chennh@imm.ac.cn
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