药学学报, 2019, 54(12): 2232-2239
引用本文:
张继芬, 王艳华, 李清清, 王帆, 易涛. Pickering乳液给药系统的研究进展[J]. 药学学报, 2019, 54(12): 2232-2239.
ZHANG Ji-fen, WANG Yan-hua, LI Qing-qing, WANG Fan, YI Tao. Research progress of Pickering emulsion drug delivery systems[J]. Acta Pharmaceutica Sinica, 2019, 54(12): 2232-2239.

Pickering乳液给药系统的研究进展
张继芬1, 王艳华1, 李清清1, 王帆1, 易涛2
1. 西南大学药学院, 重庆 400716;
2. 澳门理工学院健康科学及体育高等学校, 澳门 999078
摘要:
Pickering乳液是通过固体微粒吸附于乳滴界面起到稳定作用的一种新型乳液,较传统的表面活性剂乳液具有更好的抗合并稳定性和安全性,近年来在药剂学方面的应用受到越来越多的关注。除了皮肤给药之外,最近还出现了新型口服和注射的Pickering乳液给药系统,可以减少表面活性剂对皮肤的刺激性、促进药物经皮吸收、提高药物口服吸收和稳定性、控制药物释放和靶向给药,以及作为新型免疫佐剂的载体等,显示出广阔的应用前景。影响Pickering乳液给药系统构建的因素很多,尚未见报道对这些影响因素进行系统分析。本文总结了Pickering乳液在药剂学领域的研究应用,探讨了作为药物载体的Pickering乳液的制备和评价,尤其是固体微粒、油相、制备工艺及各因素的交互作用对Pickering乳液给药系统构建的影响,分析了Pickering乳液给药系统研究的主要挑战和未来方向,以期为Pickering乳液给药系统的深入研究提供参考。
关键词:    Pickering乳液      给药系统      固体微粒      纳米晶      口服      经皮      注射     
Research progress of Pickering emulsion drug delivery systems
ZHANG Ji-fen1, WANG Yan-hua1, LI Qing-qing1, WANG Fan1, YI Tao2
1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China;
2. School of Health Sciences and Sports, Macao Polytechnic Institute, Macau 999078, China
Abstract:
Pickering emulsion is a new type of emulsion which is stabilized by the adsorption of solid particles on the interface of emulsion droplets. In recent years, its applications in pharmacy have attracted more and more attention because of its higher resistance to coalescence and better safety than traditional surfactant emulsions. The Pickering emulsion was first used for topical administration to reduce skin irritation of surfactants and promote transdermal absorption of drugs. Recently, new oral and injectable Pickering emulsions have also been reported, which can promote oral absorption of insoluble drugs, improve stability of drugs, control drug release, targeted-delivery drugs, and serve as the carrier for novel immunological adjuvants. All these studies show Pickering emulsion a promising drug delivery system. However, its development in pharmacy is still in its infancy. There are many factors influencing the preparation of Pickering emulsions. But there is no systematic analysis of these factors up to now. In this review, we gave an overview of Pickering emulsions from their application in pharmaceutical field, preparation and evaluation, focusing on the effects of solid particles, oil phase, preparation technology and interaction of various factors on the fabrication of Pickering emulsions. The challenges and future directions of this exciting and rapidly expanding research area were further commented on, in order to provide reference for the in-depth study of Pickering emulsion drug delivery systems.
Key words:    Pickering emulsion    drug delivery system    solid particle    nanocrystal    oral    topical    injection   
收稿日期: 2019-06-27
DOI: 10.16438/j.0513-4870.2019-0519
基金项目: 国家自然科学基金资助项目(81603304);重庆市卫生局中医药科技项目(ZY201701004);中央高校基本科研业务费重点项目(XDJK2019B033);澳门特别行政区科学技术发展基金资助(001/2016/A1);澳门理工学院资助研究项目(RP/ESS-01/2018).
通讯作者: 易涛,Tel:86-0853-85993471,E-mail:yiaaron@outlook.com
Email: yiaaron@outlook.com
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