药学学报, 2019, 54(12): 2240-2250
官娟, 陆伟跃, 占昌友. 血浆蛋白对脂质体体内性能的调控[J]. 药学学报, 2019, 54(12): 2240-2250.
GUAN Juan, LU Wei-yue, ZHAN Chang-you. Plasma proteins regulating in vivo performance of liposomes[J]. Acta Pharmaceutica Sinica, 2019, 54(12): 2240-2250.

官娟1,2, 陆伟跃2, 占昌友1,2
1. 复旦大学基础医学院, 上海 200032;
2. 复旦大学药学院, 智能化递药教育部和全军重点实验室, 上海 201203
关键词:    脂质体      蛋白冠      体内性能      临床转化      生物标记物     
Plasma proteins regulating in vivo performance of liposomes
GUAN Juan1,2, LU Wei-yue2, ZHAN Chang-you1,2
1. School of Basic Medical Sciences, Fudan University, Shanghai 200032, China;
2. Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
Liposomes have been widely exploited in clinics. After entry into blood stream, liposomes absorb a large number of plasma proteins to form protein corona, which severely regulates in vivo performance of liposomes. It is of high importance to study the relationships among liposome surface properties, plasma protein components and liposome in vivo performance for clinical translation. In this review, we will summarize the factors affecting liposome protein corona, the effects of protein corona on liposome performance and the rational design of liposomes, aiming to accelerate clinical translation of liposome-based therapeutics.
Key words:    liposome    protein corona    in vivo performance    clinical translation    biomarker   
收稿日期: 2019-07-30
DOI: 10.16438/j.0513-4870.2019-0611
基金项目: 国家自然科学基金资助项目(81673361,81973245);中国博士后创新人才支持计划(BX20190086);上海市科委“科技创新行动计划”(19431900300,18ZR1404800).
通讯作者: 占昌友,Tel:86-21-54237379,E-mail:cyzhan@fudan.edu.cn
Email: cyzhan@fudan.edu.cn
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陆伟跃  在本刊中的所有文章
占昌友  在本刊中的所有文章

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