药学学报, 2019, 54(12): 2277-2281
引用本文:
江虹雨, 钟思雨, 吴利苹, 俞雅芮, 陆世惠, 李玲蕊, 李成容, 安梦琪, 黄静. 丹桂中的一个新降倍半萜苷[J]. 药学学报, 2019, 54(12): 2277-2281.
JIANG Hong-yu, ZHONG Si-yu, WU Li-ping, YU Ya-rui, LU Shi-hui, LI Ling-rui, LI Cheng-rong, AN Meng-qi, HUANG Jing. A new sesquiterpene glycoside from Osmanthus fragrans var. aurantiacus[J]. Acta Pharmaceutica Sinica, 2019, 54(12): 2277-2281.

丹桂中的一个新降倍半萜苷
江虹雨, 钟思雨, 吴利苹, 俞雅芮, 陆世惠, 李玲蕊, 李成容, 安梦琪, 黄静
四川大学华西药学院, 四川 成都 610041
摘要:
为了对丹桂(Osmanthus fragrans var.aurantiacus)干花进行化学成分研究,利用硅胶、MCI、聚酰胺等柱色谱和半制备反相高效液相色谱从丹桂干花95%乙醇提取物中分离得到1个新化合物(1)和5个已知化合物(2~6),通过理化性质和一维核磁共振(1H-、13C-NMR、DEPT)、二维核磁共振(1H-1H COSY、非去偶HSQC、HSQC、HMBC)、紫外光谱、红外光谱以及高分辨质谱等波谱数据鉴定化合物结构,分别鉴定为(9S)-9-hydroxymengastigm-5-en-4-one-9-O-primeveroside(1)、齐墩果酸(2)、连翘脂素(3)、红景天苷酯(4)、红景天苷(5)和类叶升麻苷(6)。化合物1为新化合物,其他化合物均为首次从该植物中分离得到。
关键词:    木犀科      桂花      丹桂      降倍半萜苷     
A new sesquiterpene glycoside from Osmanthus fragrans var. aurantiacus
JIANG Hong-yu, ZHONG Si-yu, WU Li-ping, YU Ya-rui, LU Shi-hui, LI Ling-rui, LI Cheng-rong, AN Meng-qi, HUANG Jing
West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Abstract:
The chemical constituents were isolated and purified by column chromatography and semi-preparative reversed-phase high performance liquid chromatography with silica gel, MCI and polyamide in order to study the chemical constituents of dried flowers of Osmanthus fragrans var. aurantiacus. Their structures were identified by the physical and chemical properties and one-dimensional nuclear magnetic resonance (1H-, 13C-NMR, DEPT), two-dimensional nuclear magnetic resonance (1H-1H COSY, non-decoupled HSQC, HSQC, HMBC), UV, IR and high resolution mass spectrometry data. One new compound (1) and five known compounds (2-6) were isolated from 95% ethanol extract of dried broccoli. They were identified as (9S)-9-hydroxymengastigm-5-en-4-one-9-O-primeveroside (1), oleanolic acid (2), forsythiaside (3), 2-(4-hydroxyphenethyl)-ethanol-(6-acetyl)-β-D-glucopyranoside (4), salidroside (5), and acteoside (6). Compounds (2-6) were isolated from this plant for the first time.
Key words:    Oleaceae    Osmanthus fragrans    Osmanthus fragrans var. aurantiacus    sesquiterpene glycoside   
收稿日期: 2019-07-08
DOI: 10.16438/j.0513-4870.2019-0535
通讯作者: 黄静,Tel:86-28-85503045,E-mail:huangj_pharm@scu.edu.cn
Email: huangj_pharm@scu.edu.cn
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