药学学报, 2019, 54(12): 2286-2288
引用本文:
马洁, 吉腾飞, 田晋, 王彦改, 杨建波, 苏亚伦, 王爱国. 贯叶金丝桃中一个新的2,3-二氧代黄酮[J]. 药学学报, 2019, 54(12): 2286-2288.
MA Jie, JI Teng-fei, TIAN Jin, WANG Yan-gai, YANG Jian-bo, SU Ya-lun, WANG Ai-guo. A new 2,3-dioxoflavonoid from the aerial part of Hypericum perforatum[J]. Acta Pharmaceutica Sinica, 2019, 54(12): 2286-2288.

贯叶金丝桃中一个新的2,3-二氧代黄酮
马洁, 吉腾飞, 田晋, 王彦改, 杨建波, 苏亚伦, 王爱国
中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
摘要:
利用硅胶柱色谱、Sephedax LH-20、制备高效液相色谱等分离、纯化方法,从贯叶金丝桃(Hypericum perforatum L.)中分离得到一个新的黄酮类化合物,其结构经UV、IR、MS、HR-ESI-MS及核磁共振等波谱技术鉴定为:Rel-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2-methoxy-3-(2-oxopropyl)chroman-4-one(1)。化合物1是一个含有一个丙酮基的2,3-二氧代黄酮类化合物,在自然界中较为罕见。此外,还对该化合物的可能生源途径进行了推测。
关键词:    贯叶金丝桃      化学成分      2,3-二氧代黄酮     
A new 2,3-dioxoflavonoid from the aerial part of Hypericum perforatum
MA Jie, JI Teng-fei, TIAN Jin, WANG Yan-gai, YANG Jian-bo, SU Ya-lun, WANG Ai-guo
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Phytochemical study of the aerial parts of Hypericum perforatum L. resulted in the isolation of an undescribed compound, which was identified as Rel-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2-methoxy-3-(2-oxopropyl)chroman-4-one (1) by spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR spectra. Compound 1 is a new 2,3-dioxo-flavone with an acetonyl moiety, rarely found in nature. In addition, a plausible biogenetic pathway of 1 was proposed in this article.
Key words:    Hypericum perforatum    chemical constituents    2,3-dioxoflavone   
收稿日期: 2019-08-01
DOI: 10.16438/j.0513-4870.2019-0618
基金项目: 北京市自然科学基金青年项目(7194299);中国医学科学院医学与健康科技创新工程(CAMS-I2M-1-010).
通讯作者: 王爱国,Tel/Fax:86-10-63165327,E-mail:wangaiguo@imm.ac.cn
Email: wangaiguo@imm.ac.cn
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参考文献:
[1] Editorial Committee of Flora of China. Flora of China (中国植物志)[M]. Beijing:Science Press, 1990:21.
[2] Xie ZW, Yu YQ. Name of Chinese Herbal Medicine (全国中草药名鉴上册)[M]. Beijing:People's Medical Publishing House, 1996:350.
[3] Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China (中华人民共和国药典一部)[S]. Part 1. Beijing:China Medical Science Press, 2015, 231.
[4] Barnes J, Anderson LA, Phillipson JD. St John's wort (Hypericum perforatum L.):a review of its chemistry, pharmacology and clinical properties[J]. J Pharm Pharmacol, 2001, 53:583-600.
[5] Ma J, Yang JB, Ji TF, et al. Chemical constituents from Hypericum perforatum[J]. China J Chin Mater Med (中国中药杂志), 2012, 37:2408-2412.
[6] Dewick PM. Medicinal Natural Products:A Biosynthetic Approach[M]. 3rd Ed. Chichester:John Wiley and Sons, 2009.