药学学报, 2020, 55(1): 8-14
郑文鸽, 秦雪梅, 高丽, 杜冠华. 衰老相关分泌表型的作用机制及相关药物研究进展[J]. 药学学报, 2020, 55(1): 8-14.
ZHENG Wen-ge, QIN Xue-mei, GAO Li, DU Guan-hua. Research advances in understanding the senescence-associated secretory phenotype and relevant drugs[J]. Acta Pharmaceutica Sinica, 2020, 55(1): 8-14.

郑文鸽1,2, 秦雪梅1, 高丽1, 杜冠华3
1. 山西大学中医药现代研究中心, 山西 太原 030006;
2. 山西大学化学化工学院, 山西 太原 030006;
3. 中国医学科学院、北京协和医学院药物研究所, 北京 100050
衰老相关分泌表型(senescence-associated secretory phenotype,SASP)是促炎因子、趋化因子和蛋白酶等一系列细胞因子的总称,是衰老细胞的关键特征。SASP是一柄双刃剑,在正常细胞中能抵御外界有害环境,但随着身体机能下降,SASP大量分泌,在诱发机体炎症的同时,加速机体衰老,导致多种衰老相关疾病的产生。本文概述了SASP的组成及其生理功能、SASP在衰老过程中的变化、调节途径以及调节SASP的抗衰老药物,旨在对SASP有一个更加全面深刻的认识,为基于SASP的抗衰老机制研究及相关药物新靶点的发现奠定基础。
关键词:    衰老相关分泌表型      衰老细胞      通路      药物     
Research advances in understanding the senescence-associated secretory phenotype and relevant drugs
ZHENG Wen-ge1,2, QIN Xue-mei1, GAO Li1, DU Guan-hua3
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;
2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China;
3. Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of a series of cytokines such as pro-inflammatory factors, chemokines and proteases, and is a key feature of senescent cells. SASP is a double-edged sword that can resist a harmful environment in normal cells, but with the decline of body function, the massive secretion of cytokines, chemokines and proteases accelerates aging while inducing inflammation, leading to the development of various aging-related diseases. This article reviews the composition and physiological functions of SASP, the changes in SASP during aging, the regulatory pathways associated with SASP, and the anti-aging drugs that regulate SASP. This article aims to present a more comprehensive understanding of SASP and lay the foundation for SASP-based anti-aging research and the discovery of new targets for anti-SASP drugs.
Key words:    senescence-associated secretory phenotype    senescent cell    pathway    drug   
收稿日期: 2019-07-25
DOI: 10.16438/j.0513-4870.2019-0603
基金项目: 国家自然科学青年基金资助项目(81603319);山西省面上青年基金资助项目(201801D221374).
通讯作者: 高丽,Tel:86-351-7018379,E-mail:gaoli87@sxu.edu.cn;杜冠华,Tel:86-10-63165184,E-mail:dugh@imm.ac.cn
Email: gaoli87@sxu.edu.cn;dugh@imm.ac.cn
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