药学学报, 2020, 55(1): 25-32
何佳彧, 梁菊, 宣茂松, 吴文澜. 提高多肽体内稳定性的有效策略[J]. 药学学报, 2020, 55(1): 25-32.
HE Jia-yu, LIANG Ju, XUAN Mao-song, WU Wen-lan. Effective strategies for improving the stability of peptides in vivo[J]. Acta Pharmaceutica Sinica, 2020, 55(1): 25-32.

何佳彧1, 梁菊1, 宣茂松1, 吴文澜2
1. 河南科技大学化工与制药学院, 河南 洛阳 471023;
2. 河南科技大学医学院, 河南 洛阳 471023
关键词:    多肽      稳定性      半衰期      环肽      D-型氨基酸     
Effective strategies for improving the stability of peptides in vivo
HE Jia-yu1, LIANG Ju1, XUAN Mao-song1, WU Wen-lan2
1. Chemical Engineering and Pharmaceutics School, Luoyang 471023, China;
2. Medical School, Henan University of Science and Technology, Luoyang 471023, China
Peptides have been extensively used in the fields of gene/drug delivery and disease targeting therapy. However, natural peptides are sensitive to protease digestion with short circulatory half-lives in vivo. Many studies on structural modifications of peptides have been reported to improve the delivery or therapeutic effect. In this review we focus on the recent literature on peptide stability in accordance with different structural modifications and summarize the methods and influential factors that are involved in the improvement of stability and half-life in vivo. This review will provide the scientific basis and theoretical references for further investigations and applications in vivo.
Key words:    peptide    stability    half-life    cyclic peptide    D-amino acid   
收稿日期: 2019-08-29
DOI: 10.16438/j.0513-4870.2019-0696
基金项目: 国家自然科学青年基金项目(51403055);国家自然科学联合基金项目(U1704150).
通讯作者: 梁菊,Tel:13838467989,E-mail:liangju@haust.edu.cn
Email: liangju@haust.edu.cn
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何佳彧  在本刊中的所有文章
梁菊  在本刊中的所有文章
宣茂松  在本刊中的所有文章
吴文澜  在本刊中的所有文章

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