药学学报, 2020, 55(4): 720-733
引用本文:
孙彦莹, 左晓芳, 展鹏, 刘新泳. 抗腺病毒药物化学研究新进展[J]. 药学学报, 2020, 55(4): 720-733.
SUN Yan-ying, ZUO Xiao-fang, ZHAN Peng, LIU Xin-yong. Recent advances in the discovery and development of adenovirus inhibitors[J]. Acta Pharmaceutica Sinica, 2020, 55(4): 720-733.

抗腺病毒药物化学研究新进展
孙彦莹, 左晓芳, 展鹏, 刘新泳
山东大学药学院药物化学研究所, 化学生物学教育部重点实验室, 山东 济南 250012
摘要:
腺病毒是儿童和成人急性呼吸道、胃肠道及泌尿道等部位感染的常见病原体,在免疫功能低下的人群中可引起严重甚至致死性感染,对人类的健康造成极大的威胁。目前尚无批准上市的特异性抗腺病毒药物。随着对腺病毒致病机制和生物学特征的深入研究以及药物发现筛选技术的快速发展,新一代抗腺病毒的药物靶标及其抑制剂被陆续发现,为其治疗方案提供了新的选择。本综述精选近几年最具代表性的研究实例,总结了抗腺病毒药物化学的前沿进展。
关键词:    腺病毒      药物靶标      抗腺病毒药物      小分子抑制剂      药物设计     
Recent advances in the discovery and development of adenovirus inhibitors
SUN Yan-ying, ZUO Xiao-fang, ZHAN Peng, LIU Xin-yong
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Abstract:
Adenovirus is a common cause of infection in children and adults with acute respiratory tract, gastrointestinal tract and urinary tract. It can cause serious and even fatal infections in patients with low immune function. Therefore, it poses a great threat to human health. Currently, there are no specific anti-adenoviral drugs in market. With in-depth investigation of the pathogenic mechanism and biological characteristics of adenovirus, and the rapid development of drug screening technology, new generation of anti-adenovirus drug targets and related inhibitors have been discovered, providing new options for treatment. This review selects the representative case studies in recent years and summarizes the advances in anti-adenoviral medicinal chemistry.
Key words:    adenovirus    drug target    anti-adenovirus agent    small molecule inhibitor    drug design   
收稿日期: 2019-11-25
DOI: 10.16438/j.0513-4870.2019-0947
基金项目: 国家自然科学基金重点国际合作研究项目(81420108027);山东省重大科技创新工程资助(2019JZZY021011,2017CXGC1401).
通讯作者: 刘新泳,Tel:86-531-88380270,E-mail:xinyongl@sdu.edu.cn;展鹏,E-mail:zhanpeng1982@sdu.edu.cn
Email: xinyongl@sdu.edu.cn;zhanpeng1982@sdu.edu.cn
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