药学学报, 2020, 55(4): 734-743
张涛, 周忠霞, 展鹏, 刘新泳. 抗痘病毒药物化学研究新进展[J]. 药学学报, 2020, 55(4): 734-743.
ZHANG Tao, ZHOU Zhong-xia, ZHAN Peng, LIU Xin-yong. New progress in medicinal chemistry of anti-poxvirus drugs research[J]. Acta Pharmaceutica Sinica, 2020, 55(4): 734-743.

张涛, 周忠霞, 展鹏, 刘新泳
山东大学药学院药物化学研究所, 化学生物学教育部重点实验室, 山东 济南 250012
关键词:    痘病毒      正痘病毒      抑制剂      靶点      药物设计     
New progress in medicinal chemistry of anti-poxvirus drugs research
ZHANG Tao, ZHOU Zhong-xia, ZHAN Peng, LIU Xin-yong
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Poxvirus is the largest and most complex virus of the known virions, and the main pathogenicity to humans is Orthopoxvirus. In recent years, with the deep understanding of the biological structure and replication cycle of Orthopoxvirus, new small molecular compounds with high efficiency and low toxicity have been discovered as new drugs, and some have entered the clinical trial stage. This article summarizes the research progress of poxvirus inhibitors with different targets.
Key words:    poxvirus    Orthopoxvirus    inhibitor    target    drug design   
收稿日期: 2019-11-26
DOI: 10.16438/j.0513-4870.2019-0954
基金项目: 国家自然科学基金重点国际合作研究项目(81420108027);山东省重点研发计划(2017CXGC1401,2019JZZY021011).
通讯作者: 刘新泳,Tel:86-531-88380270,E-mail:xinyongl@sdu.edu.cn;展鹏,E-mail:zhanpeng1982@sdu.edu.cn
Email: xinyongl@sdu.edu.cn;zhanpeng1982@sdu.edu.cn
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