药学学报, 2020, 55(10): 2243-2255
引用本文:
乔露瑶, 张晓伟. “异常肝再生”的发生机制及其在肝纤维化治疗中的作用[J]. 药学学报, 2020, 55(10): 2243-2255.
QIAO Lu-yao, ZHANG Xiao-wei. Mechanism of “aberrant liver regeneration” and its role in treatment of liver fibrosis[J]. Acta Pharmaceutica Sinica, 2020, 55(10): 2243-2255.

“异常肝再生”的发生机制及其在肝纤维化治疗中的作用
乔露瑶, 张晓伟
中国医学科学院、北京协和医学院药物研究所, 北京 100050
摘要:
肝纤维化是酒精性肝病、病毒性肝炎和结节性肝硬化等多种慢性肝病的核心病理改变,而肝再生则是肝脏对抗多种损伤、促进炎症转归并逆转肝纤维化的关键机制。当肝脏受到损伤发生纤维化时,纤维化肝脏再生状态的改变通常对多种肝病的转归起到重要作用。本文从发生条件、肝脏基础状态、对肝脏修复的影响、涉及到的细胞种类及发生机制等方面对“稳态肝再生”、“正常肝再生”与“异常肝再生”进行区别,重点总结“正常肝再生”和“异常肝再生”的发生机制,详细介绍了常用肝纤维化模型中的“异常肝再生”情况并进行总结,基于“异常肝再生”的发生机制探究了与其相关的肝纤维化治疗策略,并考虑其潜在风险,以期对临床肝纤维化的治疗提供借鉴依据。
关键词:    肝再生      肝硬化      肝细胞      星形细胞     
Mechanism of “aberrant liver regeneration” and its role in treatment of liver fibrosis
QIAO Lu-yao, ZHANG Xiao-wei
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Liver fibrosis is a critical pathological structural basis of a variety of chronic liver diseases such as alcoholic liver disease, viral hepatitis and nodular cirrhosis, while liver regeneration is the key mechanism for protecting liver against multiple injuries, promoting inflammation resolution and reversing liver fibrosis. When fibrosis occurs after liver injuries, the alternation of liver regeneration status in fibrosis usually plays an essential role in the outcome of diverse liver diseases. In this review, the differences between "homeostatic regeneration", "normal regeneration" and "aberrant regeneration" were identified in terms of the occurrence conditions, the basic state of the liver, the effects on liver repair, the types of cells involved and the pathogenesis. Emphatically, we not only summarize the differences of mechanisms between "aberrant regeneration" and "normal regeneration" in the pathogenesis of liver fibrosis, but also elucidate the features of "aberrant regeneration" in various liver fibrosis models, as well as the therapeutic strategies for the treatment of liver fibrosis based on "aberrant regeneration", expecting to provide evidence and clues for considering the risks and proposing possible solutions in clinical treatment of liver fibrosis.
Key words:    liver regeneration    cirrhosis    hepatocyte    hepatic stellate cell   
收稿日期: 2020-03-10
DOI: 10.16438/j.0513-4870.2020-0282
基金项目: 国家自然科学基金资助项目(81773800);中国医学科学院医学与健康科技创新工程重大协同创新项目(2016-I2M-1-010).
通讯作者: 张晓伟,Tel:86-10-83161187,E-mail:zhxw@imm.ac.cn
Email: zhxw@imm.ac.cn
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