药学学报, 2020, 55(11): 2491-2500
张旭, 蒙凌华. 源于天然产物或其衍生物的分子靶向抗肿瘤药物研究进展[J]. 药学学报, 2020, 55(11): 2491-2500.
ZHANG Xu, MENG Ling-hua. Progress in molecularly targeted anti-tumor drugs derived from natural products or their derivatives[J]. Acta Pharmaceutica Sinica, 2020, 55(11): 2491-2500.

张旭, 蒙凌华
中国科学院上海药物研究所, 上海 201203
关键词:    分子靶向      抗肿瘤药物      药物发现      天然产物      衍生物     
Progress in molecularly targeted anti-tumor drugs derived from natural products or their derivatives
ZHANG Xu, MENG Ling-hua
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Conventional chemotherapy drugs, molecularly targeted drugs, and immune checkpoint inhibitors are the major constituents of anti-tumor drugs in clinical settings at present. Molecularly targeted drugs specifically target the key proteins, genes, or signal transduction pathways in tumor cells which are essential for initiation and development of tumor, resulting in selective activity to induce cell death or growth inhibition. Molecularly targeted drugs have emerged as the mainstream in the research and development of anti-tumor drugs due to its high selectivity and low toxicity. Natural products refer to the chemical constituents or metabolites originated animals, plants, or microorganisms, which have been recognized as one of the important sources of drug discovery with abundant resources and diversified structures. At present, a number of molecularly targeted anti-tumor drugs derived from natural products or their derivatives have been approved for cancer therapy or in clinical trials. This review will summarize the molecularly targeted anti-tumor drugs derived from natural products or their derivatives according to their different cellular targets, and also outline the molecular mechanism, progress, and perspectives of these drugs.
Key words:    molecularly targeted    anti-tumor drug    drug discovery    natural product    derivative   
收稿日期: 2020-03-06
DOI: 10.16438/j.0513-4870.2020-0248
基金项目: 国家自然科学基金资助项目(81973345).
通讯作者: 蒙凌华,Tel:86-21-50801669,E-mail:lhmeng@simm.ac.cn
Email: lhmeng@simm.ac.cn
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张旭  在本刊中的所有文章
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