药学学报, 2020, 55(12): 2800-2810
吴军, 于海波. 大麻二酚在神经精神疾病中的作用与分子机制研究进展[J]. 药学学报, 2020, 55(12): 2800-2810.
WU Jun, YU Hai-bo. Recent advances in understanding the roles and molecular mechanisms of cannabidiol in neuropsychiatric disorders[J]. Acta Pharmaceutica Sinica, 2020, 55(12): 2800-2810.

吴军, 于海波
中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
大麻(Cannabis sativa)是一种古老的药用植物,常被用于缓解疼痛和癫痫性发作。然而,大麻素具有成瘾性,这限制了它们的临床使用。大麻二酚(cannabidiol,CBD)作为一种没有精神活性的大麻成分,不良反应明显小于Δ9-四氢大麻酚(Δ9-tetrahydrocannabinol,THC),因此受到了广泛关注。研究发现,CBD对多种神经精神疾病均有改善作用,但具体的作用机制尚未明确。由于它与经典的大麻素受体间的亲和力低,越来越多的研究开始关注内源性大麻素系统以外的其他靶点。本综述主要总结CBD在癫痫、神经病理性疼痛、焦虑症和抑郁症中的作用和分子机制。
关键词:    大麻二酚      神经元兴奋性      离子通道      G蛋白偶联受体      神经精神疾病     
Recent advances in understanding the roles and molecular mechanisms of cannabidiol in neuropsychiatric disorders
WU Jun, YU Hai-bo
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China
Cannabis sativa, one of the ancient medicinal plants, has been used to alleviate pain and seizures. However, cannabinoids are often addictive, which limits their clinical use. Cannabidiol (CBD) as a non-psychoactive component of Cannabis sativa, has much weaker adverse effects than Δ9-tetrahydrocannabinol (THC) and therefore has received widespread attention. CBD has been found to ameliorate a variety of neuropsychiatric diseases, but the precise mechanism(s) of action are still unclear. Due to its low affinity for classical cannabinoid receptors current studies are focusing on other targets outside the endocannabinoid system. In the present review we mainly summarize the effects and molecular mechanisms of CBD in neuropsychiatric disorders, including epilepsy, neuropathic pain, anxiety, and depression.
Key words:    cannabidiol    neuronal excitability    ion channel    G-protein-coupled receptor    neuropsychiatric disorder   
收稿日期: 2020-05-02
DOI: 10.16438/j.0513-4870.2020-0672
基金项目: 重大新药创制科技重大专项(2018ZX09711001-004-001);新药作用机制研究与药效评价北京市重点实验室(BZ0150).
通讯作者: 于海波,Tel:86-10-83165742,E-mail:haiboyu@imm.ac.cn
Email: haiboyu@imm.ac.cn
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