药学学报, 2020, 55(12): 2811-2817
引用本文:
王诺琦, 杨秀颖, 杜冠华. 影响糖尿病伤口愈合机制研究进展[J]. 药学学报, 2020, 55(12): 2811-2817.
WANG Nuo-qi, YANG Xiu-ying, DU Guan-hua. Advances in research on mechanisms of diabetic wound healing[J]. Acta Pharmaceutica Sinica, 2020, 55(12): 2811-2817.

影响糖尿病伤口愈合机制研究进展
王诺琦, 杨秀颖, 杜冠华
中国医学科学院、北京协和医学院药物研究所, 药物靶点研究与新药筛选北京市重点实验室, 北京 100050
摘要:
伤口愈合是一个复杂的、高度调节的过程,是维持皮肤屏障功能的关键。糖尿病患者的伤口存在缓慢甚至不愈合的情况,可导致糖尿病足和截肢,是造成糖尿病高致残率的主要并发症,严重情况下可威胁患者生命。表面伤口的愈合需要多种因素的协同作用,使受伤的皮肤恢复其屏障功能。造成糖尿病伤口愈合困难的机制较为复杂,包括氧化应激、慢性长期的炎症、新生血管的减少、末梢神经病变、细胞外基质累积及重塑的失衡等。本文对其机制进行分类介绍,为其进一步研究提供参考。
关键词:    糖尿病      伤口愈合      皮肤      氧化应激      慢性炎症     
Advances in research on mechanisms of diabetic wound healing
WANG Nuo-qi, YANG Xiu-ying, DU Guan-hua
Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Wound healing is a complex and highly regulated process to maintaining the skin barrier function. Wounds of diabetic patients are hard or even not healing. Non-healing diabetic foot ulcers can lead to lower-extremity amputations. Diabetic wound healing problem is the main complication that leads to high disability rate of diabetes and can threaten the lives in severe cases. The healing of skin wounds requires the synergy of multiple factors to restore the injured skin to its barrier function. The mechanisms that cause it difficult to heal diabetic wounds are complex, including oxidative stress, chronic inflammation, decreased neovascularization, peripheral neuropathy, and imbalance of extracellular matrix accumulation and remodeling. This review classifies mechanisms of diabetic wound healing and provides a reference for its further research.
Key words:    diabetes    wound healing    skin    oxidative stress    chronic inflammation   
收稿日期: 2020-06-09
DOI: 10.16438/j.0513-4870.2020-0933
基金项目: 国家重大研发项目(2018ZX09711001-012,2018ZX09711001-003-005,2017YFG0112900);国家自然科学基金资助项目(81470159,81770847);中国医学科学院医学与健康科技创新工程协同创新团队项目(CAMSI2M,2016-I2M-3-007,2017-I2M-1-010).
通讯作者: 杨秀颖,Tel:86-10-63165313,E-mail:lucia@imm.ac.cn;杜冠华,E-mail:dugh@imm.ac.cn
Email: lucia@imm.ac.cn;dugh@imm.ac.cn
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