药学学报, 2021, 56(2): 391-402
引用本文:
陶柱萍, 龙宇, 李灿委, 尹爱武, 范孟然, 厉颖, 刘卫红, 高鹏飞. 肠道菌群在中草药抗溃疡性结肠炎中的作用[J]. 药学学报, 2021, 56(2): 391-402.
TAO Zhu-ping, LONG Yu, LI Can-wei, YIN Ai-wu, FAN Meng-ran, LI Ying, LIU Wei-hong, GAO Peng-fei. Role of gut microbiota in the treatment of ulcerative colitis with traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2021, 56(2): 391-402.

肠道菌群在中草药抗溃疡性结肠炎中的作用
陶柱萍1, 龙宇2, 李灿委3, 尹爱武4, 范孟然1, 厉颖1, 刘卫红5, 高鹏飞1,6
1. 大理大学药学院, 云南 大理 671000;
2. 南华大学附属第二医院, 湖南 衡阳 421001;
3. 大理大学公共卫生学院, 云南 大理 671000;
4. 湘潭医卫职业技术学院, 湖南 湘潭 411104;
5. 大理大学农学与生物科学学院, 云南 大理 671000;
6. 云南省昆虫生物医药研发重点实验室, 云南 大理 671000
摘要:
溃疡性结肠炎(ulcerative colitis,UC)是一种慢性非特异性炎症性肠病,病情迁延难愈,且易反复发作,被世界卫生组织列为现代难治性疾病。UC的发病机制与肠道菌群失调密切相关。肠道菌群与胆汁酸、短链脂肪酸和色氨酸等代谢,与免疫系统以及肠黏膜屏障等的相互作用均影响UC的发生和发展。中草药活性成分、单味中草药及其提取物以及中药复方可通过影响肠道菌群的多样性、结构、组成以及代谢产物等调节肠道菌群失调,有效改善UC症状。本文整理了3年来基于调节肠道菌群治疗UC的中草药,总结其作用机制,以期为抗UC药物的进一步研究提供参考。
关键词:    溃疡性结肠炎      肠道菌群      作用机制      中药     
Role of gut microbiota in the treatment of ulcerative colitis with traditional Chinese medicine
TAO Zhu-ping1, LONG Yu2, LI Can-wei3, YIN Ai-wu4, FAN Meng-ran1, LI Ying1, LIU Wei-hong5, GAO Peng-fei1,6
1. College of Pharmacy, Dali University, Dali 671000, China;
2. The Second Hospital of Nanhua University, Hengyang 421001, China;
3. College of Public Health, Dali University, Dali 671000, China;
4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104, China;
5. College of Agriculture and Biological Science, Dali University, Dali 671000, China;
6. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali 671000, China
Abstract:
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, listed as a modern refractory disease by the World Health Organization, which is difficult to recover, whereas it is easy to be attacked repeatedly. UC pathogenesis is closely related to gut microbiota dysbiosis. The gut microbiota interacts with bile acids (BAs), short-chain fatty acids (SCFAs), tryptophan, and other metabolism, immune system, intestinal barrier, etc., which regulate each other and affect the occurrence and development of UC. The active ingredients of traditional Chinese medicine (TCM), single herb and its extracts, and formulae can effectively alleviate UC symptoms by regulating the diversity, structure, composition, and metabolites of gut microbiota. In this review, the TCM based on the regulation of gut microbiota in the treatment of UC and its related mechanism for nearly three years was summarized.
Key words:    ulcerative colitis    gut microbiota    mechanism    traditional Chinese medicine   
收稿日期: 2020-11-25
DOI: 10.16438/j.0513-4870.2020-1802
基金项目: 国家自然科学基金资助项目(81260676,81960712);云南省地方本科高校(部分)基础研究联合专项项目(2018FH001-097);云南省教育厅科学研究基金重点项目(2013Z154);云南省2019年中药饮片产业发展专项资金(2019-YG-067);中国国家留学基金(201708535007).
通讯作者: 高鹏飞,Tel:86-872-2257401,E-mail:gaodaluan@126.com
Email: gaodaluan@126.com
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