药学学报, 2021, 56(3): 761-770
引用本文:
李倩, 杜丽娜. 聚焦超声联合微泡开放血脑屏障增强脑靶向递送研究进展[J]. 药学学报, 2021, 56(3): 761-770.
LI Qian, DU Li-na. Research progress of focused ultrasound combined with microbubbles to open blood-brain barrier for brain-targeted delivery[J]. Acta Pharmaceutica Sinica, 2021, 56(3): 761-770.

聚焦超声联合微泡开放血脑屏障增强脑靶向递送研究进展
李倩1,2, 杜丽娜1,2
1. 山东中医药大学, 山东 济南 250355;
2. 军事科学院军事医学研究院辐射医学研究所, 北京 100850
摘要:
血脑屏障(blood-brain barrier,BBB)是药物脑靶向递送的最主要屏障,聚焦超声和微泡联合应用为跨BBB脑靶向递送提供了一种新途径,其主要机制为空化效应。本综述概括了近年来采用聚焦超声联合微泡增强BBB通透性实现药物脑靶向递送的相关研究,详细论述了聚焦超声及其作用机制;商品化微泡种类、常用微泡膜材、内核气体和制备方法;聚焦超声联合微泡开放BBB机制及安全性考虑等。聚焦超声联合微泡可能是增强BBB通透性、提高药物脑靶向递送的有效策略,其相关研究可为临床实际应用提供参考。
关键词:    聚焦超声      微泡      血脑屏障      脑靶向递送     
Research progress of focused ultrasound combined with microbubbles to open blood-brain barrier for brain-targeted delivery
LI Qian1,2, DU Li-na1,2
1. Shandong University of Traditional Chinese Medicine, Jinan 250355, China;
2. Beijing Institute of Radiation Medicine, Beijing 100850, China
Abstract:
Blood-brain barrier (BBB) is the most challengeable obstacle for brain-targeted drug delivery. The combination of focused ultrasound (FUS) and microbubbles provides a new way for brain-targeted drug delivery across BBB based on the cavitation effect. This review briefly described the recent research of FUS combined with microbubbles to enhance the BBB permeability for brain-targeted drug delivery. The contents included the FUS mechanism, the types of the commercial microbubbles, shell materials, inner gas and preparation techniques of microbubbles, the opening mechanism of FUS with microbubbles, and the safety consideration. FUS combined with microbubbles may be the effective strategy to improve the BBB permeability for brain-targeted delivery, which could provide references for the clinical applications.
Key words:    focused ultrasound    microbubbles    blood-brain barrier    brain-targeted delivery   
收稿日期: 2020-09-24
DOI: 10.16438/j.0513-4870.2020-1528
基金项目: 北京市自然科学基金面上项目(7202147).
通讯作者: 杜丽娜,Tel:86-10-66930216,E-mail:dulina@188.com
Email: dulina@188.com
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