药学学报, 2021, 56(4): 949-965
兰嘉琦, 赵春阳, 吴镭, 冯新红, 王庆利, 彭英. 抗焦虑障碍药物非临床药效学评价体系探索[J]. 药学学报, 2021, 56(4): 949-965.
LAN Jia-qi, ZHAO Chun-yang, WU Lei, FENG Xin-hong, WANG Qing-li, PENG Ying. Evaluation of non-clinical anxiety disorder models[J]. Acta Pharmaceutica Sinica, 2021, 56(4): 949-965.

兰嘉琦1, 赵春阳2, 吴镭1, 冯新红3, 王庆利2*, 彭英1*
1. 中国医学科学院、北京协和医学院药物研究所, 北京 100050;
2. 国家药品监督管理局药品审评中心, 北京 100022;
3. 清华大学附属北京清华长庚医院神经内科, 北京 102218
焦虑障碍(anxiety disorder)是常见的成人精神障碍,其发病是遗传与环境因素共同作用的结果。基于焦虑障碍的发病机制,已经建立了一系列测量焦虑情绪水平和诱导焦虑情绪的动物模型,并广泛应用于抗焦虑药物筛选。本综述主要介绍了焦虑障碍的研究进展,对典型的动物模型体系进行归纳,包括既可以测量焦虑情绪水平也可以诱导焦虑情绪的动物模型和只诱导焦虑情绪的动物模型。本文总结了规范化焦虑障碍动物模型在非临床研究中需要注意的问题,并对抗焦虑药物的非临床药效学研究方案的系统化和规范化提出建议。
关键词:    焦虑障碍      动物模型      行为学评价      非临床药效学评价      新药研发     
Evaluation of non-clinical anxiety disorder models
LAN Jia-qi1, ZHAO Chun-yang2, WU Lei1, FENG Xin-hong3, WANG Qing-li2*, PENG Ying1*
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
2. Center for Drug Evaluation, National Medical Product Administration, Beijing 100022, China;
3. Department of Neurology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 102218, China
Anxiety disorders are one of the most common mental disorders in adults, the cause of which derives from a combination of genetics and environmental factors. A series of animal models have been established according to their pathogenesis to measure the level of anxiety or induce anxiety only, and these models have been widely applied in the non-clinical evaluation of anxiolytics. In this review, we present the current trends in the study of anxiety disorders and summarize typical non-clinical anxiety animal models, including models that both measure anxiety levels and induce anxiety, and models that induce anxiety only. This review summarizes the important issues in standardized non-clinical research of anxiety disorders and proposes criteria for the selection of an appropriate R&D model.
Key words:    anxiety disorder    animal model    behavioristics    non-clinical pharmacodynamics    drug discovery   
收稿日期: 2020-09-29
DOI: 10.16438/j.0513-4870.2020-1569
基金项目: 国家自然科学基金资助项目(81802877);中国医学科学院医-学与健康科技创新工程(2017-I2M-2-004);国家“重大新药创制”科技重大专项(2018ZX09711001-003-005,2018ZX09711001-003-009).
通讯作者: 彭英,Tel:86-10-83165742,Fax:86-10-63017757,E-mail:ypeng@imm.ac.cn;王庆利,Tel:86-10-68585566,Fax:86-10-68584189,E-mail:wangql@cde.org.cn
Email: ypeng@imm.ac.cn;wangql@cde.org.cn
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吴镭  在本刊中的所有文章
冯新红  在本刊中的所有文章
王庆利  在本刊中的所有文章
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1.黄龙舰, 赵春阳, 冯新红, 兰嘉琦, 唐婧姝, 王庆利, 彭英.抗阿尔茨海默病药物非临床药效学评价体系的探索[J]. 药学学报, 2020,55(5): 789-805