药学学报, 2021, 56(4): 1016-1024
孙彩霞, 鞠艳敏, 戴建君. 肿瘤微环境调节型纳米材料的研究进展[J]. 药学学报, 2021, 56(4): 1016-1024.
SUN Cai-xia, JU Yan-min, DAI Jian-jun. Research progress in tumor microenvironmentally modulating nanostructures[J]. Acta Pharmaceutica Sinica, 2021, 56(4): 1016-1024.

孙彩霞1, 鞠艳敏2*, 戴建君1,2
1. 中国药科大学生命科学与技术学院, 江苏 南京 211198;
2. 中国药科大学药学院, 江苏 南京 211198
肿瘤微环境(tumor microenvironment,TME)是由免疫细胞、炎症细胞、肿瘤相关成纤维细胞、微血管,以及各种细胞因子和趋化因子所构成的一个复杂的综合系统,作为肿瘤细胞的生存环境,它与肿瘤的发生、转移及复发密切相关。肿瘤微环境的特点包括:弱酸性环境、低氧、活性氧(reactive oxygen species,ROS)及还原性物质含量高、免疫抑制性等。弱酸性环境有利于肿瘤细胞的转移;低氧有利于耐药性的出现;ROS及还原性物质含量高有利于肿瘤的治疗;免疫抑制性有利于免疫逃逸的发生。随着纳米技术的不断发展,越来越多的纳米材料被报道可通过调节肿瘤微环境进而实现肿瘤治疗。本文主要综述了纳米材料在调节肿瘤微环境中的酸碱度(hydrogen-ion concentration,pH)、氧气(oxygen,O2)含量、ROS浓度及免疫细胞活性方面的最新研究进展,并对未来的研究方向做出了展望。
关键词:    纳米材料      肿瘤微环境      酸碱度      氧气      活性氧      免疫抑制     
Research progress in tumor microenvironmentally modulating nanostructures
SUN Cai-xia1, JU Yan-min2*, DAI Jian-jun1,2
1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China;
2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Tumor microenvironment (TME) is a complex comprehensive system composed of immune cells, inflammatory cells, tumor-associated fibroblasts, microvessels, and various cytokines and chemokines. As the living environment of tumor cells, it's closely related to the occurrence, metastasis, and recurrence of tumors. The characteristics of tumor microenvironment include:weakly acidic environment, low oxygen, high concentration of reactive oxygen species (ROS) and reducing substances, immunosuppression, etc. A weakly acidic environment favors metastasis of tumor cells, hypoxia is conducive to the emergence of drug resistance, high concentration of ROS and reducing substances are beneficial for tumor treatment, and immunosuppressiveness facilitates immune escape. With the rapid development of nanotechnology, more and more nanostructures have been reported to achieve tumor treatment by regulating the tumor microenvironment. This review summarizes recent advances in the nanostructures used to regulate tumor microenvironment through changing elements, including hydrogen-ion concentration (pH), the concentration of oxygen (O2) and reactive oxygen species, and the activity of immune cells. Moreover, research directions in the future are pointed out in this review.
Key words:    nanostructure    tumor microenvironment    hydrogen-ion concentration    oxygen    reactive oxygen species    immunosuppression   
收稿日期: 2020-09-30
DOI: 10.16438/j.0513-4870.2020-1572
基金项目: 国家重点研发资助项目(2019YFC1605402);国家自然科学基金青年科学基金资助项目(52002402);江苏省优势学科颠覆性计划.
通讯作者: 鞠艳敏,Tel:86-25-86185360,E-mail:juyanmin@cpu.edu.cn
Email: juyanmin@cpu.edu.cn
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孙彩霞  在本刊中的所有文章
鞠艳敏  在本刊中的所有文章
戴建君  在本刊中的所有文章

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