药学学报, 2021, 56(5): 1314-1331
张圆圆, 杜丽娜, 金义光. 环境敏感型水凝胶在药物递送中的应用[J]. 药学学报, 2021, 56(5): 1314-1331.
ZHANG Yuan-yuan, DU Li-na, JIN Yi-guang. Application of environmentally sensitive hydrogels in drug delivery[J]. Acta Pharmaceutica Sinica, 2021, 56(5): 1314-1331.

张圆圆1,2, 杜丽娜1,2*, 金义光2
1. 山东中医药大学, 山东 济南 250355;
2. 军事科学院军事医学研究院辐射医学研究所, 北京 100850
关键词:    温度敏感型水凝胶      pH敏感型水凝胶      酶敏感型水凝胶      给药途径      聚合物      环境敏感型     
Application of environmentally sensitive hydrogels in drug delivery
ZHANG Yuan-yuan1,2, DU Li-na1,2*, JIN Yi-guang2
1. Shandong University of Traditional Chinese Medicine, Jinan 250355, China;
2. Beijing Institute of Radiation Medicine, Beijing 100850, China
Environmentally sensitive hydrogels are a novel formulation that has developed rapidly in recent years. It could form semi-solid with good adhesion in the topical sites based on different physiological environments. Its long local retention time is conducive for sustained drug release, and the preparation process is relatively simple and easy to realize industrialization. This review summarized the categories, commonly used polymer, and different administration routes based on the recently published literatures. According to different response factors, it can be divided into temperature, pH, ion, light, and multiple sensitive hydrogels, among which temperature-sensitive hydrogels are the most common. The most commonly used polymers include chitosan, poly N-isopropyl acrylamide, and poloxamer. There are different administration routes for environmentally sensitive hydrogels, such as transdermal, ophthalmic, nasal, oral, vaginal, rectal, injection, etc. Environmentally sensitive hydrogels have broad prospects in clinical application.
Key words:    temperature-sensitive hydrogel    pH-sensitive hydrogel    enzyme-sensitive hydrogel    administration route    polymer    environmentally sensitive   
收稿日期: 2020-12-04
DOI: 10.16438/j.0513-4870.2020-1873
基金项目: 北京自然科学基金面上资助项目(7202147).
通讯作者: 杜丽娜,Tel:86-10-66930216,E-mail:dulina@188.com
Email: dulina@188.com
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