药学学报, 2021, 56(5): 1434-1438
引用本文:
王洁雪, 陶果, 杨帆, 杨敏, 冯晴琴, 马明芳, 陈静. 藏药绿萝花化学成分及其降糖活性研究[J]. 药学学报, 2021, 56(5): 1434-1438.
WANG Jie-xue, TAO Guo, YANG Fan, YANG Min, FENG Qing-qin, MA Ming-fang, CHEN Jing. Chemical composition and hypoglycemic activity of Edgeworthia gardneri[J]. Acta Pharmaceutica Sinica, 2021, 56(5): 1434-1438.

藏药绿萝花化学成分及其降糖活性研究
王洁雪1, 陶果1, 杨帆1, 杨敏1, 冯晴琴1, 马明芳3, 陈静2*
1. 成都师范学院化学与生命科学学院, 功能分子结构优化与应用四川省高校重点实验室, 四川 成都 611130;
2. 西藏藏医药大学, 西藏 拉萨 850000;
3. 青海省产品质量监督检验所, 青海 西宁 810008
摘要:
采用硅胶柱色谱、凝胶色谱及高压制备色谱等方法对绿萝花的成分进行分离纯化,通过其理化性质及波谱数据对分离得到的化合物进行结构表征。从绿萝花醇提取物中共分离得到7个化合物:绿萝花苷A(1)、2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside(2)、2,6-dimethoxy-4-(2-propen-1-yl)phenyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside(3)、丁香酚芸香糖苷(4)、银锻苷(5)、结香苷C(6)和水杨酸(7)。其中1为新化合物,2~4首次从该植物中分离得到。药理活性表明,化合物12均对α-葡萄糖苷酶具有显著的抑制活性,其抑制率与阿卡波糖相当。
关键词:    藏药      绿萝花      绿萝花苷A      α-葡萄糖苷酶      化学成分     
Chemical composition and hypoglycemic activity of Edgeworthia gardneri
WANG Jie-xue1, TAO Guo1, YANG Fan1, YANG Min1, FENG Qing-qin1, MA Ming-fang3, CHEN Jing2*
1. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China;
2. Tibet University of Tibetan Medicine, Lhasa 850000, China;
3. Qinghai Province Institute for Food Control, Xining 810008, China
Abstract:
Seven compounds were isolated from the alcohol extract of Edgeworthia gardneri by various technologies, including silica gel, Sephadex LH-20 and high performance liquid chromatography, and were identified as edgeworthiaside A (1), 2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside (2), 2,6-dimethoxy-4-(2-propen-1-yl)phenyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (3), eugenol rutinoside (4), tiliroside (5), edgeworoside C (6), and salicylic acid (7). Compound 1 is a new chlorophenyl glycoside and 2-4 were isolated for the first time from Edgeworthia gardneri. The in vitro inhibition of α-glucosidase showed that the inhibition rate of compounds 1 and 2 were similar to acarbose.
Key words:    Tibetan material herb    Edgeworthia gardneri    edgeworthiaside A    α-glucosidase    chemical constituent   
收稿日期: 2020-12-28
DOI: 10.16438/j.0513-4870.2020-1970
基金项目: 四川省科技计划项目(2019YJ0440);四川省大学生创新创业项目训练计划(202014389133).
通讯作者: 陈静,Tel:15889097799,E-mail:cjttmc@sina.cn
Email: cjttmc@sina.cn
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