药学学报, 2021, 56(9): 2456-2463
引用本文:
刘羿晨, 杜婷婷, 王庆华, 张智慧, 陈晓光*. 脂质代谢与血液肿瘤[J]. 药学学报, 2021, 56(9): 2456-2463.
LIU Yi-chen, DU Ting-ting, WANG Qing-hua, ZHANG Zhi-hui, CHEN Xiao-guang*. Lipid metabolism and hematological malignancies[J]. Acta Pharmaceutica Sinica, 2021, 56(9): 2456-2463.

脂质代谢与血液肿瘤
刘羿晨, 杜婷婷, 王庆华, 张智慧, 陈晓光*
中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
摘要:
随着近年来研究的深入,肿瘤代谢重编程逐渐成为了研究的热点,靶向肿瘤细胞代谢也成为了新的肿瘤治疗手段。代谢过程影响着生物体几乎所有的生理进程,而脂代谢则是代谢过程中的重要组成部分。研究表明,多种肿瘤中发生了脂质摄取、存储和脂肪酸合成分解的变化,异常的脂质代谢会促进肿瘤快速增殖,脂质代谢过程中的多种关键代谢酶的表达异常是肿瘤进展的关键。本文旨在阐述脂质代谢及相关代谢酶在血液肿瘤中的代谢调控作用,为血液肿瘤的治疗提供思路。
关键词:    脂质代谢      脂肪酸氧化      代谢酶      血液肿瘤     
Lipid metabolism and hematological malignancies
LIU Yi-chen, DU Ting-ting, WANG Qing-hua, ZHANG Zhi-hui, CHEN Xiao-guang*
State Key Laboratory of Bioactive Substance and Function of National Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
With the deepening of research in recent years, tumor metabolic reprogramming has gradually become the focus of research, and targeting tumor cell metabolism has also become a new means of tumor therapy. The metabolic process affects almost all the physiological processes of the organism, and lipid metabolism is an important part of the metabolic process. Studies have shown that changes in lipid uptake, storage and fatty acid synthesis and decomposition have occurred in a variety of tumors. Abnormal lipid metabolism will promote the rapid proliferation of tumors. Abnormal expression of a variety of key metabolic enzymes in the process of lipid metabolism is the key to tumor progression. The purpose of this paper is to explain the metabolic regulation of lipid metabolism and related metabolic enzymes in hematological tumors, and to provide ideas for the treatment of hematological tumors.
Key words:    lipid metabolism    fatty acid oxidation    metabolic enzyme    hematological malignancy   
收稿日期: 2021-01-06
DOI: 10.16438/j.0513-4870.2021-0030
基金项目: “十三五”国家“重大新药创制”科技重大专项(2018ZX09711001-003-011).
通讯作者: 陈晓光,Tel:86-10-63165207,E-mail:chxg@imm.ac.cn
Email: chxg@imm.ac.cn
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