药学学报, 2021, 56(10): 2622-2629
许都昌, 赖开澄, 金义光, 徐远清. 肺部颗粒运动机制模型的研究进展[J]. 药学学报, 2021, 56(10): 2622-2629.
XU Du-chang, LAI Kai-cheng, JIN Yi-guang, XU Yuan-qing. Research progress of pulmonary particle movement mechanical model[J]. Acta Pharmaceutica Sinica, 2021, 56(10): 2622-2629.

许都昌1, 赖开澄1, 金义光2, 徐远清1*
1. 北京理工大学生命学院, 北京 100081;
2. 军事科学院军事医学研究院辐射医学研究所, 北京 100850
关键词:          机制模型      颗粒运动      数值模拟      格子Boltzmann方法     
Research progress of pulmonary particle movement mechanical model
XU Du-chang1, LAI Kai-cheng1, JIN Yi-guang2, XU Yuan-qing1*
1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China;
2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
The movement and deposition of inhaled particles in the lung tissue have an important influence on the respiratory physiology of human body. The corresponding particle dynamics model plays a vital role in exploring the pathogenic factors and treatment methods of lung diseases. Such as evaluating the optimal design of pulmonary atomization drug delivery and the impact of particulate air pollutants on the lung. According to the different knowledge and modeling methods, this paper classifies, combs and analyzes several representative particle dynamics models in lung airways in recent years. We divided the mechanism models into the biological model, physical model and numerical simulation model. The biological models include in vivo imaging and pharmacokinetic methods; physical models include bionic and microfluidic chip models; the numerical models include respiratory tract model, airflow model and particle model. Moreover, the numerical solution and fluid-structure-interaction models were also reviewed, especially the application prospect of the lattice Boltzmann method.
Key words:    lung    mechanical model    particle movement    numerical computer simulation    lattice Boltzmann method   
收稿日期: 2021-04-29
DOI: 10.16438/j.0513-4870.2021-0651
基金项目: 国家自然科学基金资助项目(81771935).
通讯作者: 徐远清,Tel:18513537806,E-mail:bitxyq@bitedu.cn
Email: bitxyq@bitedu.cn
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徐远清  在本刊中的所有文章

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