药学学报, 2021, 56(10): 2825-2829
引用本文:
张袁亚, 张治军, 叶瑞绒, 李蓉涛*. 越南槐根茎中的生物碱成分及其抗炎活性[J]. 药学学报, 2021, 56(10): 2825-2829.
ZHANG Yuan-ya, ZHANG Zhi-jun, YE Rui-rong, LI Rong-tao*. Alkaloids from the roots and rhizomes of Sophora tonkinensis and its anti-inflammatory activities[J]. Acta Pharmaceutica Sinica, 2021, 56(10): 2825-2829.

越南槐根茎中的生物碱成分及其抗炎活性
张袁亚, 张治军, 叶瑞绒, 李蓉涛*
昆明理工大学生命科学与技术学院, 云南 昆明 650500
摘要:
采用多种色谱技术从越南槐根茎中分离得到了25个喹诺里西啶类生物碱(包括苦参碱型114、鹰爪豆碱型1517、金雀花碱型1823、其他型2425),并依据理化性质及NMR、MS波谱数据鉴定了化合物的结构。其中12-(1-乙酰氧基乙基)-金雀花碱(23)为新的金雀花碱型衍生物,化合物13161724为首次从越南槐根茎中分离得到。化合物161920可明显抑制脂多糖(LPS)诱导小鼠巨噬细胞RAW 264.7释放NO,IC50值分别为39.86 ±0.65、23.66 ±0.37、34.56 ±0.45、47.68 ±0.58 μmol·L-1
关键词:    越南槐      喹诺里西啶类生物碱      12-(1-乙酰氧基乙基)-金雀花碱      抗炎活性     
Alkaloids from the roots and rhizomes of Sophora tonkinensis and its anti-inflammatory activities
ZHANG Yuan-ya, ZHANG Zhi-jun, YE Rui-rong, LI Rong-tao*
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
Abstract:
Twenty-five quinolizidine alkaloids (including matrine-type 1-14, sparteine-type 15-17, cytisine-type 18-23, other types 24 and 25) were isolated from the roots and rhizomes of Sophora tonkinensis by various chromatographic methods. Their structures were elucidated by physicochemical properties, NMR and MS spectral data. Among them, 12-(1-acetoxyethyl)-cytisine (23) is a new alkaloid derivative, and compounds 13, 16, 17, 24 were isolated from the roots and rhizomes of S. tonkinensis for the first time. Compounds 1, 6, 19 and 20 showed potent inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages, with IC50 values of 39.86 ±0.65, 23.66 ±0.37, 34.56 ±0.45, 47.68 ±0.58 μmol·L-1, respectively.
Key words:    Sophora tonkinensis    quinolizidine alkaloids    12-(1-acetoxyethyl)-cytisine    anti-inflammatory   
收稿日期: 2021-05-10
DOI: 10.16438/j.0513-4870.2021-0687
基金项目: 国家自然科学基金资助项目(31960092,22067012,82073737);云南省创新团队资助项目(2019HC018).
通讯作者: 李蓉涛,Tel:86-871-65920569,E-mail:rongtaolikm@163.com
Email: rongtaolikm@163.com
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