药学学报, 2021, 56(11): 3004-3013
赵欣彤, 李天磊, 张文轩*, 吴松*. 铁离子载体-抗生素偶联物的研究进展[J]. 药学学报, 2021, 56(11): 3004-3013.
ZHAO Xin-tong, LI Tian-lei, ZHANG Wen-xuan*, WU Song*. Research progress on siderophore-antibiotic conjugates[J]. Acta Pharmaceutica Sinica, 2021, 56(11): 3004-3013.

赵欣彤, 李天磊, 张文轩*, 吴松*
中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
关键词:    铁离子载体      铁离子载体-抗生素偶联物      革兰阴性菌      抗生素耐药     
Research progress on siderophore-antibiotic conjugates
ZHAO Xin-tong, LI Tian-lei, ZHANG Wen-xuan*, WU Song*
State Key Laboratory of Natural Medicine Active Substances and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
With the increasing drug resistance of bacteria, especially Gram-negative bacteria, the infection of drug-resistant bacteria has become one of the most challengeable clinical problems. The siderophore-antibiotic conjugates based on the "Trojan horse" strategy can penetrate the extracellular membrane of Gram-negative bacteria by active transport, and they are expected to become a powerful weapon for clinical anti-infection treatment. This review describes the drug design strategies of siderophore-antibiotic conjugates reported in recent years, and focuses on the use of different types of antibiotics in this strategy.
Key words:    siderophore    siderophore-antibiotic conjugate    Gram-negative bacteria    antibiotic resistance   
收稿日期: 2021-03-23
DOI: 10.16438/j.0513-4870.2021-0410
基金项目: “重大新药创制”国家科技重大专项(2018ZX09711001-005);中国医学科学院医学与健康科技创新工程重大项目(2017-I2M-2-004).
通讯作者: 张文轩,Tel:86-10-83163542,E-mail:wxzhang@imm.ac.cn;吴松,E-mail:ws@imm.ac.cn
Email: wxzhang@imm.ac.cn;ws@imm.ac.cn
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李天磊  在本刊中的所有文章
张文轩*  在本刊中的所有文章
吴松*  在本刊中的所有文章

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