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药学学报, 2022, 57(5): 1444-1447 |
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引用本文： |
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冯亚美, 张强, 尹立敏, 孙隆儒. 乳香中一个新的甘遂烷型三萜[J]. 药学学报, 2022, 57(5): 1444-1447. |
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FENG Ya-mei, ZHANG Qiang, YIN Li-min, SUN Long-ru. A new tirucallane-type triterpene from the gum resin of Boswellia carterii[J]. Acta Pharmaceutica Sinica, 2022, 57(5): 1444-1447. |
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| 乳香中一个新的甘遂烷型三萜 |
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| 冯亚美1, 张强2, 尹立敏1, 孙隆儒1* |
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1. 山东大学药学院, 山东 济南 250012;
2. 西北农林科技大学化学与药学院, 陕西 咸阳 712100 |
| 摘要: |
| 为研究乳香的化学成分，本文采用硅胶柱色谱和高效液相色谱从乳香95%乙醇浸膏中分离得到2个化合物，通过IR、UV、NMR和HR-ESI-MS等方法对其进行结构解析，并借助ECD计算确定其绝对构型，分别是：7α-羟基-3，11-二羰基-甘遂-8，24-二烯-21-酸（1）和21β-羟基-3-乙酰基-11-羰基-β-乳香酸（2），其中化合物1是新化合物，化合物2为首次采用ECD计算确定其绝对构型的已知化合物。 |
| 关键词:
乳香
四环三萜
7α-羟基-3,11-二羰基-甘遂-8,24-二烯-21-酸
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| A new tirucallane-type triterpene from the gum resin of Boswellia carterii |
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| FENG Ya-mei1, ZHANG Qiang2, YIN Li-min1, SUN Long-ru1* |
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1. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;
2. College of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, China |
| Abstract: |
| Two compounds were isolated from 95% ethanol extract of the gum resin of Boswellia carterii by silica gel column chromatography (CC) and high-performance liquid chromatography (HPLC). Their structures were identified with IR, UV, NMR and HR-ESI-MS spectroscopic data as 7α-hydroxy-3,11-dioxo- tirucalla-8,24-dien-21-oic acid (1) and 21β-hydroxy-3-acetyl-11-keto-β-boswellic acid (2). In addition, their absolute configurations were also identified by ECD calculations. Among them, compound 1 is a new compound and the absolute configuration of compound 2 is confirmed by ECD calculation for the first time. |
| Key words:
Boswellia carterii
tirucallane-type triterpene
7α-hydroxy-3,11-dioxo-tirucalla-8,24-dien-21-oic acid
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| 收稿日期: 2021-11-15
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| DOI: 10.16438/j.0513-4870.2021-1633 |
| 基金项目: 山东省自然科学基金资助项目（ZR2019MH088）. |
通讯作者: 孙隆儒,Tel:86-531-88382012,Fax:86-531-88382548,E-mail:sunlr@sdu.edu.cn
Email: sunlr@sdu.edu.cn |
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