药学学报, 2022, 57(5): 1444-1447
引用本文:
冯亚美, 张强, 尹立敏, 孙隆儒. 乳香中一个新的甘遂烷型三萜[J]. 药学学报, 2022, 57(5): 1444-1447.
FENG Ya-mei, ZHANG Qiang, YIN Li-min, SUN Long-ru. A new tirucallane-type triterpene from the gum resin of Boswellia carterii[J]. Acta Pharmaceutica Sinica, 2022, 57(5): 1444-1447.

乳香中一个新的甘遂烷型三萜
冯亚美1, 张强2, 尹立敏1, 孙隆儒1*
1. 山东大学药学院, 山东 济南 250012;
2. 西北农林科技大学化学与药学院, 陕西 咸阳 712100
摘要:
为研究乳香的化学成分,本文采用硅胶柱色谱和高效液相色谱从乳香95%乙醇浸膏中分离得到2个化合物,通过IR、UV、NMR和HR-ESI-MS等方法对其进行结构解析,并借助ECD计算确定其绝对构型,分别是:7α-羟基-3,11-二羰基-甘遂-8,24-二烯-21-酸(1)和21β-羟基-3-乙酰基-11-羰基-β-乳香酸(2),其中化合物1是新化合物,化合物2为首次采用ECD计算确定其绝对构型的已知化合物。
关键词:    乳香      四环三萜      7α-羟基-3,11-二羰基-甘遂-8,24-二烯-21-酸     
A new tirucallane-type triterpene from the gum resin of Boswellia carterii
FENG Ya-mei1, ZHANG Qiang2, YIN Li-min1, SUN Long-ru1*
1. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;
2. College of Chemistry & Pharmacy, Northwest A&F University, Xianyang 712100, China
Abstract:
Two compounds were isolated from 95% ethanol extract of the gum resin of Boswellia carterii by silica gel column chromatography (CC) and high-performance liquid chromatography (HPLC). Their structures were identified with IR, UV, NMR and HR-ESI-MS spectroscopic data as 7α-hydroxy-3,11-dioxo- tirucalla-8,24-dien-21-oic acid (1) and 21β-hydroxy-3-acetyl-11-keto-β-boswellic acid (2). In addition, their absolute configurations were also identified by ECD calculations. Among them, compound 1 is a new compound and the absolute configuration of compound 2 is confirmed by ECD calculation for the first time.
Key words:    Boswellia carterii    tirucallane-type triterpene    7α-hydroxy-3,11-dioxo-tirucalla-8,24-dien-21-oic acid   
收稿日期: 2021-11-15
DOI: 10.16438/j.0513-4870.2021-1633
基金项目: 山东省自然科学基金资助项目(ZR2019MH088).
通讯作者: 孙隆儒,Tel:86-531-88382012,Fax:86-531-88382548,E-mail:sunlr@sdu.edu.cn
Email: sunlr@sdu.edu.cn
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