药学学报, 2022, 57(5): 1448-1451
引用本文:
高盼盼, 任雅婷, 马洁, 臧应达, 杨敬芝, 张丹, 李创军*, 张东明*. 杜虹花叶中的两个新半日花烷型二萜[J]. 药学学报, 2022, 57(5): 1448-1451.
GAO Pan-pan, REN Ya-ting, MA Jie, ZANG Ying-da, YANG Jing-zhi, ZHANG Dan, LI Chuang-jun*, ZHANG Dong-ming*. Two new labdane diterpenoids from the leaves of Callicarpa formosana Rolfe[J]. Acta Pharmaceutica Sinica, 2022, 57(5): 1448-1451.

杜虹花叶中的两个新半日花烷型二萜
高盼盼, 任雅婷, 马洁, 臧应达, 杨敬芝, 张丹, 李创军*, 张东明*
中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
摘要:
采用硅胶柱色谱、MCI柱色谱、ODS柱色谱及高效液相色谱等色谱技术,从杜虹花叶95%乙醇提取物中分离得到2个新半日花烷型二萜类化合物,并通过质谱、核磁共振和ECD等波谱数据鉴定其结构,分别为13E-6β-hydroxylabda-8(17),13-dien-15-oic acid (1)和13E-7α-hydroxylabda-8(17),13-dien-15-oic acid (2)。对化合物12进行了抗氧化活性测试,均无明显活性。
关键词:    杜虹花      化学成分      半日花烷型二萜     
Two new labdane diterpenoids from the leaves of Callicarpa formosana Rolfe
GAO Pan-pan, REN Ya-ting, MA Jie, ZANG Ying-da, YANG Jing-zhi, ZHANG Dan, LI Chuang-jun*, ZHANG Dong-ming*
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Two new labdane diterpenoids were isolated from 95% ethanol extract of the leaves of Callicarpa formosana Rolfe by using silica gel column, MCI column, ODS column and HPLC. Their structures were elucidated by HR-ESI-MS, NMR and ECD spectral data. All of them are new compounds, named 13E-6β-hydroxylabda-8(17),13-dien-15-oic acid (1) and 13E-7α-hydroxylabda-8(17),13-dien-15-oic acid (2). Compounds 1 and 2 were tested for antioxidant activity, and none of them had obvious activity.
Key words:    Callicarpa formosana Rolfe    chemical composition    labdane diterpenoids   
收稿日期: 2021-12-28
DOI: 10.16438/j.0513-4870.2021-1856
基金项目: 国家重点研发计划资助项目(2019YFC1711000);国家自然科学基金资助项目(81730093).
通讯作者: 李创军,Tel:86-10-63165702,E-mail:lichuangjun@imm.ac.cn;张东明,Tel:86-10-63165227,E-mail:zhangdm@imm.ac.cn
Email: lichuangjun@imm.ac.cn;zhangdm@imm.ac.cn
相关功能
PDF(391KB) Free
打印本文
0
作者相关文章
高盼盼  在本刊中的所有文章
任雅婷  在本刊中的所有文章
马洁  在本刊中的所有文章
臧应达  在本刊中的所有文章
杨敬芝  在本刊中的所有文章
张丹  在本刊中的所有文章
李创军*  在本刊中的所有文章
张东明*  在本刊中的所有文章

参考文献:
[1] Flora of China Editorial Committee of Chinese Academy of Sciences.Flora of China (中国植物志)[M]. Vol 65. Beijing:Science Press, 1982:43.
[2] Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China:VoI 1(中华人民共和国药典:一部)[S]. Beijing:China Medical Science Press, 2020:1088.
[3] Wang YM, Wang F, Xiao H. Chemical constituents of Callicarpa formosana [J]. Chin Tradit Herb Drugs (中草药), 2011, 42:1696-1698.
[4] Hu YM, Shen YM, Gan FY, et al. Four diterpenes from Callicarpa pedunculata[J]. Biochem Syst Ecol, 2002, 30:999-1001.
[5] Lu CH, Shen YM. Water-soluble constituents from Callicarpa pedunculata[J]. Chin J Nat Med (中国天然药物), 2008, 6:176-178.
[6] Ren FZ, Qu HH, Luan XH, et al. Studies on the chemical constituents of Callicarpa bodinieri Levl.[J]. Nat Prod Res Dev (天然产物研究与开发), 2001, 13:33-34.
[7] Li DY, Yuan HD. Comparison of composition, toxicity and bacteriostasis of Callicarpa cathayana C. H. Chang and Callicarpa formosana[J]. Chin J Mod Appl Pharm (中国现代应用药学), 1992, 9:13-15.
[8] Lin CZ, Zhu CC, Zhang CX. Chemical constituents and antioxidant activity of the essential oils from the leaves of Callicarpa formosana.[J]. J Trop Subtrop Bot (热带亚热带植物学报), 2009, 17:401-405.
[9] Gao XL. Inhibitory effect of extracts from the fruit of Callicarpa formosana on HEP-2 cell line[J]. J Guiyang Med Coll (贵阳医学院学报), 2001, 26:523.
[10] Sun XC. Studies on the Chemical Constituents and Anti-inflammatory Activities from Callicarpa nudiflora and Ligularia fischeri (裸花紫珠和山紫菀植物化学成分及抗炎活性研究)[D]. Tianjin:Nankai University, 2017.
[11] Chen JJ, Wu HM, Peng CF, et al. Seco-abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima[J]. J Nat Prod, 2009, 72:223-228.
[12] Jones WP, Loboecheverri T, Mi Q, et al. Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida[J]. J Nat Prod, 70:372-377.
[13] Gao JB, Yang SJ, Yan ZR, et al. Isolation, characterization, and structure-activity relationship analysis of abietane diterpenoids from Callicarpa bodinieri as spleen tyrosine tinase inhibitors[J]. J Nat Prod, 2018, 81:998-1006.
[14] Corlay N, Lecso-Bornet M, Leborgne E, et al. Antibacterial labdane diterpenoids from Vitex vestita[J]. J Nat Prod, 2015, 78:1348-1356.
[15] Lopes L, Bolzani V. Lignans and diterpenes of three Aristolochia species[J]. Phytochemistry, 1988, 27:2265-2268.