药学学报, 2002, 37(2): 144-147
引用本文:
袁耀佐;胡昌勤;金少鸿. 他唑巴坦中结晶水的研究[J]. 药学学报, 2002, 37(2): 144-147.
YUAN Yao-zuo; HU Chang-qin; JIN Shao-hong. STUDY ON WATER OF CRYSTALLIZATION IN TAZOBACTAM[J]. Acta Pharmaceutica Sinica, 2002, 37(2): 144-147.

他唑巴坦中结晶水的研究
袁耀佐;胡昌勤;金少鸿
1. 江苏省药品检验所, 江苏 南京 210008; 2. 中国药品生物制品检定所, 北京 100050
摘要:
目的考察国产他唑巴坦中是否结合有结晶水。方法采用卡尔费休氏水分测定法、干燥失重、热重分析法、热差分析法、单晶X-射线衍射的方法对他唑巴坦中的水分进行研究。结果用不同的常规水分测定方法对同一批他唑巴坦测定的结果有明显的差异。结论国产他唑巴坦1分子结合有0.5分子结晶水,结晶水与他唑巴坦分子结合紧密。
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STUDY ON WATER OF CRYSTALLIZATION IN TAZOBACTAM
YUAN Yao-zuo; HU Chang-qin; JIN Shao-hong
Abstract:
AIMTo investigate whether tazobctam has crystallization water. METHODSIn order to establish a method for water content determination in tazobctam, many methods including Karl Fischer titration, weight loss on drying, TGA, DSC and X-ray diffraction experiment of an orthorhombic form were studied. RESULTSThe water content of the same batch tazobactam determined by different mthods was different. CONCLUSIONThe results showed that one mole tazobatam contains half mole water of crystallization and the strength of attraction between tazobatam molecule and water molecule is rather strong.
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