Reviews
Qihao Wu, Bastien Nay, Min Yang, Yeke Ni, Hong Wang, Ligong Yao, Xuwen Li. Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects[J]. Acta Pharmaceutica Sinica B, 2019, 9(2): 237-257

Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects
Qihao Wua,b, Bastien Nayc, Min Yanga, Yeke Nia, Hong Wangb, Ligong Yaoa, Xuwen Lia
a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China;
b College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China;
c Laboratoire de Synthèse Organique (UMR 7652 CNRS), Ecole Polytechnique, Université Paris-Saclay, 91128 Palaiseau Cedex, France
Abstract:
Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
Key words:    Marine natural products    Stelletta sponge    Isolation    Total synthesis    Biological activity    Marine drug leads   
Received: 2018-07-24     Revised: 2018-09-20
DOI: 10.1016/j.apsb.2018.10.003
Funds: This paper is dedicated to Prof.Dr.Yuewei Guo on the occasion of his 60th birthday,for his pioneer work on Chinese marine natural product chemistry.This work was supported by the National Natural Science Foundation of China (NSFC,Nos.41676073,81520108028),the National Natural Science Foundation of China/Centre National de la Recherché Scientifique (NSFC/CNRS) joint project (No.81811530284), "Youth Innovation Promotion Association" (No.2016258) from Chinese Academy of Sciences,the SA-SIBS Scholarship Program,and the National Key Research and Development Program (2017YFE0103100).
Corresponding author: Xuwen Li     Email:xwli@simm.ac.cn
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Qihao Wu
Bastien Nay
Min Yang
Yeke Ni
Hong Wang
Ligong Yao
Xuwen Li

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