Original Articles
Rui Liu, Chuan Hu, Yuanyuan Yang, Jingqing Zhang, Huile Gao. Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment[J]. Acta Pharmaceutica Sinica B, 2019, 9(2): 410-420

Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment
Rui Liua, Chuan Hua, Yuanyuan Yanga, Jingqing Zhangb, Huile Gaoa
a Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;
b Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, China
Abstract:
Although progress has been indeed made by nanomedicines, their efficacies for cancer treatment remain low, consequently leading to failures in translation to clinic. To improve the drug delivery efficiency, nanoparticles need to change size so as to fully utilize the enhanced permeability and retention (EPR) effect of solid tumor, which is the golden principle of nanoparticles used for cancer treatment. Herein, we employed cationic small-sized red emission bovine serum albumin (BSA) protected gold nanocluster (AuNC@CBSA, 21.06 nm) to both load indocyanine green (ICG) and act as imaging probe to realize theranostic. Then AuNC@CBSA-ICG was fabricated with negatively charged hyaluronic acid (HA) to form AuNC@CBSAICG@HA, which was about 200 nm to easily retain at tumor site and could be degraded by tumor-specific hyaluronidase into small nanoparticles for deep tumor penetration. The HA shell also endowed AuNC@CBSA-ICG@HA with actively targeting ability and hyaluronidase-dependent drug release. Furthermore, the quenching and recovery of fluorescence revealed the interaction between ICG and carrier, which was essential for the investigation of pharmacokinetic profiles. No matter in vitro or in vitro, AuNC@CBSAICG@HA showed markedly anti-tumor effect, and could suppress 95.0% of tumor growth on mice breast cancer model. All results demonstrated AuNC@CBSA-ICG@HA was potential for breast cancer therapy.
Key words:    Size-shrinkage    Drug release    Photothermal therapy    Theranostic    Breast cancer   
Received: 2018-05-29     Revised: 2018-08-02
DOI: 10.1016/j.apsb.2018.09.001
Funds: The work was supported by National Natural Science Foundation of China (No.81872806 and 31571016).
Corresponding author: Huile Gao     Email:gaohuile@scu.edu.cn
Author description:
Service
PDF(KB) Free
Print
0
Authors
Rui Liu
Chuan Hu
Yuanyuan Yang
Jingqing Zhang
Huile Gao

References:
1. Kievit FM, Zhang M. Cancer nanotheranostics:improving imaging and therapy by targeted delivery across biological barriers. Adv Mater 2011;23:H217-47.
2. Tang F, Li L, Chen D. Mesoporous silica nanoparticles:synthesis, biocompatibility and drug delivery. Adv Mater 2012;24:1504-34.
3. Barreto JA, O'Malley W, Kubeil M, Graham B, Stephan H, Spiccia L. Nanomaterials:applications in cancer imaging and therapy. Adv Mater 2011;23:H18-40.
4. Mitragotri S, Lahann J. Materials for drug delivery:innovative solutions to address complex biological hurdles. Adv Mater 2012;24:3717-23.
5. Dou Y, Guo Y, Li X, Li X, Wang S, Wang L, et al. Size-tuning ionization to optimize gold nanoparticles for simultaneous enhanced CT imaging and radiotherapy. ACS Nano 2016;10:2536-48.
6. Tang L, Yang X, Yin Q, Cai K, Wang H, Chaudhury I, et al. Investigating the optimal size of anticancer nanomedicine. Proc Natl Acad Sci U S A 2014;111:15344-9.
7. Popovic Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, et al. A nanoparticle size series for in vivo fluorescence imaging. Angew Chem 2010;49:8649-52.
8. Ruan S, Cao X, Cun X, Hu G, Zhou Y, Zhang Y, et al. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials 2015;60:100-10.
9. Li HJ, Du JZ, Liu J, Du XJ, Shen S, Zhu YH, et al. Smart superstructures with ultrahigh pH-sensitivity for targeting acidic tumor microenvironment:instantaneous size switching and improved tumor penetration. ACS Nano 2016;10:6753-61.
10. Kim J, Lee YM, Kang Y, Kim WJ. Tumor-homing, size-tunable clustered nanoparticles for anticancer therapeutics. ACS Nano 2014;8:9358-69.
11. Tong R, Chiang HH, Kohane DS. Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A 2013;110:19048-53.
12. Yu Y, Zhang X, Qiu L. The anti-tumor efficacy of curcumin when delivered by size/charge-changing multistage polymeric micelles based on amphiphilic poly(b-amino ester) derivates. Biomaterials 2014;35:3467-79.
13. Zhang K, Yang PP, Zhang JP, Wang L, Wang H. Recent advances of transformable nanoparticles for theranostics. Chin Chem Lett 2017;28:1808-16.
14. Hu C, Cun X, Ruan S, Liu R, Xiao W, Yang X, et al. Enzymetriggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy. Biomaterials 2018;168:64-75.
15. Zhang L, Gao S, Zhang F, Yang K, Ma Q, Zhu L. Activatable hyaluronic acid nanoparticle as a theranostic agent for optical/photoacoustic image-guided photothermal therapy. ACS Nano 2014;8:12250-8.
16. Li W, Yi X, Liu X, Zhang Z, Fu Y, Gong T. Hyaluronic acid ionpairing nanoparticles for targeted tumor therapy. J Control Release 2016;225:170-82.
17. Zhang Q, Deng C, Fu Y, Sun X, Gong T, Zhang Z. Repeated administration of hyaluronic acid coated liposomes with improved pharmacokinetics and reduced immune response. Mol Pharm 2016;13:1800-8.
18. Wang Y, Jiang Y, Zhang M, Tan J, Liang J, Wang H, et al. Proteaseactivatable hybrid nanoprobe for tumor imaging. Adv Funct Mater 2014;24:5443-53.
19. Ting CY, Fan CH, Liu HL, Huang CY, Hsieh HY, Yen TC, et al. Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment. Biomaterials 2012;33:704-12.
20. Nance E, Timbie K, Miller GW, Song J, Louttit C, Klibanov AL, et al. Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. J Control Release 2014;189:123-32.
21. Wu X, He X, Wang K, Xie C, Zhou B, Qing Z. Ultrasmall nearinfrared gold nanoclusters for tumor fluorescence imaging in vivo. Nanoscale 2010;2:2244-9.
22. Xu J,Shang L.,Emerging applications of near-infrared fluorescent metal nanoclusters for biological imaging. Chin Chem Lett 2018. Available from:http://dx.doi.org/10.1016/j.cclet.2017.12.020.
23. Cui HD, Hu DH, Zhang JN, Gao GH, Zheng CF, Gong P, et al. Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy. Chin Chem Lett 2017;28:1391-8.
24. Xie J, Zheng Y, Ying JY. Protein-directed synthesis of highly fluorescent gold nanoclusters. J Am Chem Soc 2009;131:888-9.
25. Zhou F, Feng B, Yu H, Wang D, Wang T, Liu J, et al. Cisplatin prodrug-conjugated gold nanocluster for fluorescence imaging and targeted therapy of the breast cancer. Theranostics 2016;6:679-87.
26. Khandelia R, Bhandari S, Pan UN, Ghosh SS, Chattopadhyay A. Gold nanocluster embedded albumin nanoparticles for two-photon imaging of cancer cells accompanying drug delivery. Small 2015;11:4075-81.
27. Liang C, Diao S, Wang C, Gong H, Liu T, Hong G, et al. Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes. Adv Mater 2014;26:5646-52.
28. Chen Q, Liang C, Wang C, Liu Z. An imagable and photothermal "Abraxane-like" nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors. Adv Mater 2015;27:903-10.
29. Tong H, Lou K, Wang W. Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease. Acta Pharm Sin B 2015;5:25-33.
30. Zhao J, Chen J, Ma S, Liu Q, Huang L, Chen X, et al. Recent developments in multimodality fluorescence imaging probes. Acta Pharm Sin B 2018;8:320-38.
31. Thole M, Nobmann S, Huwyler J, Bartmann A, Fricker G. Uptake of cationzied albumin coupled liposomes by cultured porcine brain microvessel endothelial cells and intact brain capillaries. J Drug Target 2002;10:337-44.
32. Hu C, Yang X, Liu R, Ruan S, Zhou Y, Xiao W, et al. Coadministration of iRGD with multistage responsive nanoparticles enhanced tumor targeting and penetration abilities for breast cancer therapy. ACS Appl Mater Interfaces 2018;10:22571-9.
33. Wong C, Dai F. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proc Natl Acad Sci U S A 2011;108:2426.
34. Deckert T, Kofoed-Enevoldsen A, Vidal P, Nørgaard K, Andreasen HB, Feldt-Rasmussen B. Size-and charge selectivity of glomerular filtration in type 1 (insulin-dependent) diabetic patients with and without albuminuria. Diabetologia 1993;36:244-51.
35. Xiao W, Xiong J, Zhang S, Xiong Y, Zhang H, Gao H. Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability. Int J Pharm 2018;538:105-11.
36. Shu Y, Gao H. Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy. Pharm Res 2017;126:97-108.