Original Articles
Rui Liu, Chuan Hu, Yuanyuan Yang, Jingqing Zhang, Huile Gao. Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment[J]. Acta Pharmaceutica Sinica B, 2019, 9(2): 410-420

Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment
Rui Liua, Chuan Hua, Yuanyuan Yanga, Jingqing Zhangb, Huile Gaoa
a Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;
b Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing 400016, China
Although progress has been indeed made by nanomedicines, their efficacies for cancer treatment remain low, consequently leading to failures in translation to clinic. To improve the drug delivery efficiency, nanoparticles need to change size so as to fully utilize the enhanced permeability and retention (EPR) effect of solid tumor, which is the golden principle of nanoparticles used for cancer treatment. Herein, we employed cationic small-sized red emission bovine serum albumin (BSA) protected gold nanocluster (AuNC@CBSA, 21.06 nm) to both load indocyanine green (ICG) and act as imaging probe to realize theranostic. Then AuNC@CBSA-ICG was fabricated with negatively charged hyaluronic acid (HA) to form AuNC@CBSAICG@HA, which was about 200 nm to easily retain at tumor site and could be degraded by tumor-specific hyaluronidase into small nanoparticles for deep tumor penetration. The HA shell also endowed AuNC@CBSA-ICG@HA with actively targeting ability and hyaluronidase-dependent drug release. Furthermore, the quenching and recovery of fluorescence revealed the interaction between ICG and carrier, which was essential for the investigation of pharmacokinetic profiles. No matter in vitro or in vitro, AuNC@CBSAICG@HA showed markedly anti-tumor effect, and could suppress 95.0% of tumor growth on mice breast cancer model. All results demonstrated AuNC@CBSA-ICG@HA was potential for breast cancer therapy.
Key words:    Size-shrinkage    Drug release    Photothermal therapy    Theranostic    Breast cancer   
Received: 2018-05-29     Revised: 2018-08-02
DOI: 10.1016/j.apsb.2018.09.001
Funds: The work was supported by National Natural Science Foundation of China (No.81872806 and 31571016).
Corresponding author: Huile Gao     Email:gaohuile@scu.edu.cn
Author description:
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Rui Liu
Chuan Hu
Yuanyuan Yang
Jingqing Zhang
Huile Gao

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