Jian Yang, Xinli Liu, Yunzhi Fu, Yujun Song. Recent advances of microneedles for biomedical applications: drug delivery and beyond[J]. Acta Pharmaceutica Sinica B, 2019, 9(3): 469-483

Recent advances of microneedles for biomedical applications: drug delivery and beyond
Jian Yanga, Xinli Liub, Yunzhi Fua, Yujun Songb
a College of Materials Science and Chemical Engineering, Hainan University, Haikou 570228, China;
b College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China
The microneedle (MN), a highly efficient and versatile device, has attracted extensive scientific and industrial interests in the past decades due to prominent properties including painless penetration, low cost, excellent therapeutic efficacy, and relative safety. The robust microneedle enabling transdermal delivery has a paramount potential to create advanced functional devices with superior nature for biomedical applications. In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP). Importantly, a variety of representative biomedical applications of microneedles such as disease treatment, immunobiological administration, disease diagnosis and cosmetic field, are highlighted in detail. At last, conclusions and future perspectives for development of advanced microneedles in biomedical fields have been discussed systematically. Taken together, as an emerging tool, microneedles have showed profound promise for biomedical applications.
Key words:    Microneedle patches    Biomedical applications    Microfabricated device    Drug delivery    Disease treatment    Disease diagnosis    Immunobiological administration    3D printing   
Received: 2018-11-27     Revised:
DOI: 10.1016/j.apsb.2019.03.007
Funds: This work was financially supported by the National Natural Science Foundation of China (Grants Nos. 21874066, 81601632 and 21563009, China) and the Natural Science Foundation of Jiangsu Province (BK20160616, China), the Fundamental Research Funds for Central Universities (China), the Shuangchuang Program of Jiangsu Province (China), and Thousand Talents Program for Young Researchers (China).
Corresponding author: Yunzhi Fu, Yujun Song;
Author description:
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Jian Yang
Xinli Liu
Yunzhi Fu
Yujun Song

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