Annual reviews
Chong Li, Jiancheng Wang, Yiguang Wang, Huile Gao, Gang Wei, Yongzhuo Huang, Haijun Yu, Yong Gan, Yongjun Wang, Lin Mei, Huabing Chen, Haiyan Hu, Zhiping Zhang, Yiguang Jin. Recent progress in drug delivery[J]. Acta Pharmaceutica Sinica B, 2019, 9(6): 1145-1162

Recent progress in drug delivery
Chong Lia, Jiancheng Wangb, Yiguang Wangb, Huile Gaoc, Gang Weid, Yongzhuo Huange, Haijun Yue, Yong Gane, Yongjun Wangf, Lin Meig, Huabing Chenh, Haiyan Hui, Zhiping Zhangj, Yiguang Jink
a College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;
b Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;
c Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;
d Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China;
e Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
f School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;
g School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China;
h School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China;
i School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;
j School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
k Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015-2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
Key words:    Pharmaceutics    Drug delivery system    Basic research    Application    Delivery strategy   
Received: 2019-04-29     Revised: 2019-07-10
DOI: 10.1016/j.apsb.2019.08.003
Funds: This review paper was supported by the projects of National Natural Science Foundation of China (Grant Nos. 81773650, 81690264 and 81673376), the Drug Innovation Major Project of China (Grant No. 2018ZX09721003-004).
Corresponding author: Jiancheng Wang
Author description:
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Chong Li
Jiancheng Wang
Yiguang Wang
Huile Gao
Gang Wei
Yongzhuo Huang
Haijun Yu
Yong Gan
Yongjun Wang
Lin Mei
Huabing Chen
Haiyan Hu
Zhiping Zhang
Yiguang Jin

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