Reviews
Chenyang Xiang, Yuxuan Zhang, Weisheng Guo, Xing-Jie Liang. Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication[J]. Acta Pharmaceutica Sinica B, 2020, 10(2): 239-248

Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication
Chenyang Xianga, Yuxuan Zhangb, Weisheng Guoa, Xing-Jie Lianga,b
a Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China;
b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
Abstract:
Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. At present, the relevant reviews are not available yet. Herein we summarized the latest advances on the biomedical and therapeutic applications of CNTs in vitro and in vivo for neurological diseases treatments as inherent therapeutic drugs. The biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely discussed. It is expected that CNTs will exploit further neurological applications on disease therapy in the near future.
Key words:    Carbon nanotubes    Nervous system diseases    Drug delivery    Therapeutic drug    Inherent medication    Toxicity   
Received: 2019-04-30     Revised: 2019-08-26
DOI: 10.1016/j.apsb.2019.11.003
Funds: This work was supported by the National Natural Science Foundation of China (31971302, 31430031, 81601603).
Corresponding author: Weisheng Guo, Xing-Jie Liang     Email:tjuguoweisheng@126.com;liangxj@nanoctr.cn
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Chenyang Xiang
Yuxuan Zhang
Weisheng Guo
Xing-Jie Liang

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