Original articles
Yixian Zhou, Boyi Niu, Biyuan Wu, Sulan Luo, Jintao Fu, Yiting Zhao, Guilan Quan, Xin Pan, Chuanbin Wu. A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility[J]. Acta Pharmaceutica Sinica B, 2020, 10(12): 2404-2416

A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility
Yixian Zhoua, Boyi Niua, Biyuan Wua, Sulan Luoa, Jintao Fua, Yiting Zhaoa, Guilan Quanb, Xin Pana, Chuanbin Wua
a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;
b College of Pharmacy, Jinan University, Guangzhou 510632, China
Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous particles can effectively enhance the aerosolization performance and bioavailability of drugs. However, the existing methods for preparing porous particles using porogens have several drawbacks, such as the inhomogeneous and uncontrollable pores, drug leakage, and high risk of fragmentation. In this study, a series of cyclodextrin-based metal-organic framework (CD-MOF) particles containing homogenous nanopores were delicately engineered without porogens. Compared with commercial inhalation carrier, CDMOF showed excellent aerosolization performance because of the homogenous nanoporous structure. The great biocompatibility of CD-MOF in pulmonary delivery was also confirmed by a series of experiments, including cytotoxicity assay, hemolysis ratio test, lung function evaluation, in vivo lung injury markers measurement, and histological analysis. The results of ex vivo fluorescence imaging showed the high deposition rate of CD-MOF in lungs. Therefore, all results demonstrated that CD-MOF was a promising carrier for pulmonary drug delivery. This study may throw light on the nanoporous particles for effective pulmonary administration.
Key words:    Pulmonary drug delivery    Metal-organic framework    Inhalable dry powder    Nanoporous particle   
Received: 2020-03-13     Revised: 2020-05-24
DOI: 10.1016/j.apsb.2020.07.018
Funds: This work was supported by the National Natural Science Foundation of China (Grant No. 81803466), the Research and Development Plan for Key Areas in Guangdong Province (Grant No. 2019B020204002, China), the National Science and Technology Major Program (Grant No. 2017zx09101001, China), and Natural Science Foundation of Guangdong Province (Grant No. 2018A030310095, China).
Corresponding author: Guilan Quan, xiaoplanet@163.com;Chuanbin Wu, wuchuanb@mail.sysu.edu.cn     Email:xiaoplanet@163.com;wuchuanb@mail.sysu.edu.cn
Author description:
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Yixian Zhou
Boyi Niu
Biyuan Wu
Sulan Luo
Jintao Fu
Yiting Zhao
Guilan Quan
Xin Pan
Chuanbin Wu

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