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Pei Wang, Fang Wang, Lan Ni, Pengfei Wu, Jianguo Chen. Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder[J]. Acta Pharmaceutica Sinica B, 2021, 11(3): 599-608

Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder
Pei Wanga, Fang Wanga,b,c,d, Lan Nia, Pengfei Wua,c, Jianguo Chena,b,c,d
a Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
b Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan 430030, China;
c The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, China;
d Laboratory of Neuropsychiatric Diseases, the Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract:
Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity via altering functions of key proteins, such as N-methyl-D-aspartate receptor (NMDAR). Age-related cognitive disorders includes Alzheimer’s disease (AD), vascular dementia (VD), and age-associated memory impairment (AAMI). Based on the critical role of NMDAR-dependent long-term potentiation (LTP) in memory, the increase of reactive oxygen species in cognitive disorders, and the sensitivity of NMDAR to the redox status, converging lines have suggested the redox-altered NMDAR-dependent plasticity might underlie the synaptic dysfunctions associated with cognitive disorders. In this review, we summarize the involvement of redox-altered plasticity in cognitive disorders by presenting the available evidence. According to reports from our laboratory and other groups, this “redox-altered plasticity” is more similar to functional changes rather than organic injuries, and strategies targeting redox-altered plasticity using pharmacological agents might reverse synaptic dysfunctions and memory abnormalities in the early stage of cognitive disorders. Targeting redox modifications for NMDARs may serve as a novel therapeutic strategy for memory deficits.
Key words:    Reactive oxygen species    N-Methyl-D-aspartate receptor    Oxidative stress    Synaptic plasticity    Long-term potentiation    Cognitive disorder    Learning and memory    Hydrogen sulfide   
Received: 2020-08-09     Revised: 2020-09-22
DOI: 10.1016/j.apsb.2020.11.012
Funds: This work was supported by grants from the National Natural Science Foundation of China (No. 81773712 to Pengfei Wu, Nos. 81471377 and 81671438 to Fang Wang, Nos. 81473198 and 81673414 to Jianguo Chen) and Foundation for Innovative Research Groups of NSFC (No. 81721005 to Jianguo Chen and Fang Wang, China).
Corresponding author: Pengfei Wu, Jianguo Chen     Email:chenj@mails.tjmu.edu.cn;wupengfeihust@sina.com
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Pei Wang
Fang Wang
Lan Ni
Pengfei Wu
Jianguo Chen

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