Reviews
Qingqing Xiao, Xiaotong Li, Yi Li, Zhenfeng Wu, Chenjie Xu, Zhongjian Chen, Wei He. Biological drug and drug delivery-mediated immunotherapy[J]. Acta Pharmaceutica Sinica B, 2021, 11(4): 941-960

Biological drug and drug delivery-mediated immunotherapy
Qingqing Xiaoa, Xiaotong Lia, Yi Lia, Zhenfeng Wub, Chenjie Xuc, Zhongjian Chend, Wei Hed,a
a School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;
b Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;
c Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, China;
d Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China
Abstract:
The initiation and development of major inflammatory diseases, i.e., cancer, vascular inflammation, and some autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy is exerting a critical role against these diseases, whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo, poor penetration across biological barriers, and rapid clearance by the reticuloendothelial system. Drug delivery strategies are potent to promote their delivery. Herein, we reviewed the potential targets for immunotherapy against the major inflammatory diseases, discussed the biologics and drug delivery systems involved in the immunotherapy, particularly highlighted the approved therapy tactics, and finally offer perspectives in this field.
Key words:    Inflammatory diseases    Cancer immunotherapy    Atherosclerosis    Pulmonary artery hypertension    Biologics    Adoptive cell transfer    Immune targets    Drug delivery   
Received: 2020-09-25     Revised: 2020-11-03
DOI: 10.1016/j.apsb.2020.12.018
Funds: This study was supported by the National Natural Science Foundation of China (Nos. 81872823 and 82073782), the Double FirstClass (CPU2018PZQ13, China) of the China Pharmaceutical University, the Shanghai Science and Technology Committee (No. 19430741500, China), the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine (TCM-201905, China), and the Start-up Grant from City University of Hong Kong (No. 9610472, China).
Corresponding author: Wei He, weihe@cpu.edu.cn     Email:weihe@cpu.edu.cn
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Qingqing Xiao
Xiaotong Li
Yi Li
Zhenfeng Wu
Chenjie Xu
Zhongjian Chen
Wei He

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