Songtao Dong, Xiangnan Guo, Fei Han, Zhonggui He, Yongjun Wang. Emerging role of natural products in cancer immunotherapy[J]. Acta Pharmaceutica Sinica B, 2022, 12(3): 1163-1185

Emerging role of natural products in cancer immunotherapy
Songtao Donga, Xiangnan Guoa, Fei Hanb, Zhonggui Hea, Yongjun Wanga
a. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China;
b. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Cancer immunotherapy has become a new generation of anti-tumor treatment, but its indications still focus on several types of tumors that are sensitive to the immune system. Therefore, effective strategies that can expand its indications and enhance its efficiency become the key element for the further development of cancer immunotherapy. Natural products are reported to have this effect on cancer immunotherapy, including cancer vaccines, immune-check points inhibitors, and adoptive immune-cells therapy. And the mechanism of that is mainly attributed to the remodeling of the tumor-immunosuppressive microenvironment, which is the key factor that assists tumor to avoid the recognition and attack from immune system and cancer immunotherapy. Therefore, this review summarizes and concludes the natural products that reportedly improve cancer immunotherapy and investigates the mechanism. And we found that saponins, polysaccharides, and flavonoids are mainly three categories of natural products, which reflected significant effects combined with cancer immunotherapy through reversing the tumor-immunosuppressive microenvironment. Besides, this review also collected the studies about nano-technology used to improve the disadvantages of natural products. All of these studies showed the great potential of natural products in cancer immunotherapy.
Key words:    Natural products    Cancer immunotherapy    Immunosuppressive microenvironment    Cancer vaccines    Immuno-check points    Adoptive immune-cells transfer immunotherapy   
Received: 2021-04-06     Revised: 2021-06-05
DOI: 10.1016/j.apsb.2021.08.020
Funds: This work was supported by Science and Technology Plan Project of Shenyang (RC200406, China) and the Career Development Program for Young and Middle-aged Teachers in Shenyang Pharmaceutical University (Shenyang, China).
Corresponding author: Fei Han,;Zhonggui He,;Yongjun Wang,;;
Author description:
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Songtao Dong
Xiangnan Guo
Fei Han
Zhonggui He
Yongjun Wang

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