Acta Pharmaceutica Sinica B


2016 Vol. 6 No. 5, 2016-10-25

Editor Profile

Editor Profiles: Guest Editors of Special Issue on Drug Metabolism and Pharmacokinetics

2016 , 6(5): 359-360  

Abstract ()     Html (0)    PDF ()

Editorial

Advanced knowledge in drug metabolism and pharmacokinetics

Ai-Ming Yu, Xiao-bo Zhong

2016 , 6(5): 361-362  

Abstract ()     Html (0)    PDF ()

Reviews

Renal drug transporters and their significance in drug-drug interactions

Jia Yin, Joanne Wang

2016 , 6(5): 363-373  

Abstract ()     Html (0)    PDF ()

An update on the role of intestinal cytochrome P450 enzymes in drug disposition

Fang Xie, Xinxin Ding, Qing-Yu Zhang

2016 , 6(5): 374-383  

Abstract ()     Html (0)    PDF ()

Isoniazid metabolism and hepatotoxicity

Pengcheng Wang, Komal Pradhan, Xiao-bo Zhong, Xiaochao Ma

2016 , 6(5): 384-392  

Abstract ()     Html (0)    PDF ()

Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

Hong Lu

2016 , 6(5): 393-408  

Abstract ()     Html (0)    PDF ()

Fatty liver diseases, bile acids, and FXR

Yan Zhu, Hongxia Liu, Min Zhang, Grace L. Guo

2016 , 6(5): 409-412  

Abstract ()     Html (0)    PDF ()

Insights into CYP2B6-mediated drug-drug interactions

William D. Hedrich, Hazem E. Hassan, Hongbing Wang

2016 , 6(5): 413-425  

Abstract ()     Html (0)    PDF ()

Exposure to inorganic arsenic can lead to gut microbe perturbations and hepatocellular carcinoma

Jonathan Choiniere, Li Wang

2016 , 6(5): 426-429  

Abstract ()     Html (0)    PDF ()

PBPK modeling and simulation in drug research and development

Xiaomei Zhuang, Chuang Lu

2016 , 6(5): 430-440  

Abstract ()     Html (0)    PDF ()

PXR variants:the impact on drug metabolism and therapeutic responses

C. Trent Brewer, Taosheng Chen

2016 , 6(5): 441-449  

Abstract ()     Html (0)    PDF ()

A brief history of the discovery of PXR and CAR as xenobiotic receptors

Jiong Yan, Wen Xie

2016 , 6(5): 450-452  

Abstract ()     Html (0)    PDF ()

Original Articles

Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

Lai Peng, Stephanie Piekos, Grace L. Guo, Xiao-bo Zhong

2016 , 6(5): 453-459  

Abstract ()     Html (0)    PDF ()

Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

Hong Shen, Lifei Wang, Weiqi Chen, Krista Menard, Yang Hong, Yuan Tian, Samuel J. Bonacorsi, W. Griffith Humphreys, Francis Y. Lee, Jinping Gan

2016 , 6(5): 460-467  

Abstract ()     Html (0)    PDF ()

Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration

Wenli Liu, Xiaona Wang, Ruilian Chen, Kaixuan Zhang, Yao Li, Yi Li, Duanyun Si, Junbo Gong, Dianshu Yin, Yongli Wang, Zhenping Wei, Mingshi Yang

2016 , 6(5): 468-474  

Abstract ()     Html (0)    PDF ()

Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine

Shinhee Park, Sunny Lihua Cheng, Julia Yue Cui

2016 , 6(5): 475-491  

Abstract ()     Html (0)    PDF ()

Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

Xi-Ling Jiang, Hong-Wu Shen, Donald E. Mager, Stephan Schmidt, Ai-Ming Yu

2016 , 6(5): 492-503  

Abstract ()     Html (0)    PDF ()

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

Sung-joon Cho, Miaoran Ning, Yanyan Zhang, Leah H. Rubin, Hyunyoung Jeong

2016 , 6(5): 504-509  

Abstract ()     Html (0)    PDF ()

Virtual Special Issue

Editorial of Virtual Special Issue on Progress in Medicinal Chemistry

Xiangming Guan

2016 , 6(5): 510-511  

Abstract ()     Html (0)    PDF ()