Acta Pharmaceutica Sinica B


2018 Vol. 8 No. 4, 2018-08-25

Special Column: Targeted Cancer Therapy

Editor Profiles: Guest Editor of Special Column on Targeted Cancer Therapy

2018 , 8(4): 499-500  

Abstract ()     Html (0)    PDF ()

Editorial Preface for Targeted Cancer Therapy

Guan Che, Wei Li

2018 , 8(4): 501-502  

Abstract ()     Html (0)    PDF ()

Reviews

Understanding the biology of HER3 receptor as a therapeutic target in human cancer

Hui Lyu, Amy Han, Erik Polsdofer, Shuang Liu, Bolin Liu

2018 , 8(4): 503-510  

Abstract ()     Html (0)    PDF ()

Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy

Xiao-Mei Qi, Fang Wang, Matthew Mortensen, Ryan Wertz, Guan Chen

2018 , 8(4): 511-517  

Abstract ()     Html (0)    PDF ()

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies

Brandon Bumbaca, Wei Li

2018 , 8(4): 518-529  

Abstract ()     Html (0)    PDF ()

Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective

Wenxiao Jiang, Guiqing Cai, Peter C. Hu, Yue Wang

2018 , 8(4): 530-538  

Abstract ()     Html (0)    PDF ()

The application of CAR-T cell therapy in hematological malignancies: advantages and challenges

Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang, Minhao Wu

2018 , 8(4): 539-551  

Abstract ()     Html (0)    PDF ()

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

Feifei Liu, Xiaotong Yang, Meiyu Geng, Min Huang

2018 , 8(4): 552-562  

Abstract ()     Html (0)    PDF ()

Original Articles

Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo

Zhiqiang Zhang, Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaona Fang, Min Luo, Chunling Ma, Jianhua Xu, Shirong Yan, Liwu Fu

2018 , 8(4): 563-574  

Abstract ()     Html (0)    PDF ()

Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway

Jia Xiao, Feiyue Xing, Yingxia Liu, Yi Lv, Xiaogang Wang, Ming-Tat Ling, Hao Gao, Songying Ouyang, Min Yang, Jiang Zhu, Yu Xia, Kwok-Fai So, George L. Tipoe

2018 , 8(4): 575-586  

Abstract ()     Html (0)    PDF ()

Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy

Xichuan Tang, Liwei Tan, Kun Shi, Jinrong Peng, Yao Xiao, Wenting Li, Lijuan Chen, Qian Yang, Zhiyong Qian

2018 , 8(4): 587-601  

Abstract ()     Html (0)    PDF ()

Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer

Pallabita Chowdhury, Prashanth K. B. Nagesh, Sheema Khan, Bilal B. Hafeez, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu

2018 , 8(4): 602-614  

Abstract ()     Html (0)    PDF ()

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

Xu-Nian Wu, Ya-Dan Huang, Jin-Xuan Li, Yan-Fa Yu, Qian Zhou, Chen Zhang, Yinuo Wu, Hai-Bin Luo

2018 , 8(4): 615-628  

Abstract ()     Html (0)    PDF ()

Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents

Xin Zhang, Qiang Liu, Qianqian Li, Yinghong Li, Zhandong Liu, Hongbin Deng, Sheng Tang, Yanxiang Wang, Youchun Wang, Danqing Song

2018 , 8(4): 629-638  

Abstract ()     Html (0)    PDF ()

Limonoids from seeds of Azadirachta indica A. Juss. and their cytotoxic activity

Jian Chen, Xiaona Fan, Jianhua Zhu, Liyan Song, Zhiwei Li, Fei Lin, Rongmin Yu, Hanhong Xu, Jiachen Zi

2018 , 8(4): 639-644  

Abstract ()     Html (0)    PDF ()

Authentic compound-free strategy for simultaneous determination of primary coumarins in Peucedani Radix using offline high performance liquid chromatography-nuclear magnetic resonance spectroscopy-tandem mass spectrometry

Yao Liu, Qingqing Song, Wenjing Liu, Peng Li, Jun Li, Yunfang Zhao, Liang Zhang, Pengfei Tu, Yitao Wang, Yuelin Song

2018 , 8(4): 645-654  

Abstract ()     Html (0)    PDF ()

In situ monitoring of the structural change of microemulsions in simulated gastrointestinal conditions by SAXS and FRET

Xia Lv, Shuguang Zhang, Huipeng Ma, Peipei Dong, Xiaodong Ma, Ming Xu, Yan Tian, Zeyao Tang, Jinyong Peng, Haibo Chen, Jianbin Zhang

2018 , 8(4): 655-665  

Abstract ()     Html (0)    PDF ()

Genome-wide characterization and analysis of bHLH transcription factors in Panax ginseng

Yang Chu, Shuiming Xiao, He Su, Baosheng Liao, Jingjing Zhang, Jiang Xu, Shilin Chen

2018 , 8(4): 666-677  

Abstract ()     Html (0)    PDF ()

Biocatalytic access to diverse prenylflavonoids by combining a regiospecific C-prenyltransferase and a stereospecific chalcone isomerase

Jianhua Li, Ridao Chen, Ruishan Wang, Xiao Liu, Kebo Xie, Dawei Chen, Jungui Dai

2018 , 8(4): 678-686  

Abstract ()     Html (0)    PDF ()

Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids

Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu

2018 , 8(4): 687-697  

Abstract ()     Html (0)    PDF ()