Acta Pharmaceutica Sinica B


2020 Vol. 10 No. 9, 2020-09-25

Reviews

Recent advances of antibody drug conjugates for clinical applications

Pengxuan Zhao, Yuebao Zhang, Wenqing Li, Christopher Jeanty, Guangya Xiang, Yizhou Dong

2020 , 10(9): 1589-1600  

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Targeting necroptosis in anticancer therapy: mechanisms and modulators

Ying Wu, Guoqiang Dong, Chunquan Sheng

2020 , 10(9): 1601-1618  

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Original articles

Icariside II, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation

Zhilei Wang, Guang Xu, Hongbo Wang, Xiaoyan Zhan, Yuan Gao, Nian Chen, Ruisheng Li, Xueai Song, Yuming Guo, Ruichuang Yang, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao, Zhaofang Bai

2020 , 10(9): 1619-1633  

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Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia-ereperfusion injury

Xiaoling Chen, Jingliang Zhang, Yan Song, Pan Yang, Yang Yang, Zhuo Huang, Kewei Wang

2020 , 10(9): 1634-1645  

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Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription

Ze Wang, Haihua Shang, Yazhuo Li, Chen Zhang, Yan Dong, Tao Cui, Hongbing Zhang, Xiaoyan Ci, Xiulin Yi, Tiejun Zhang, Fengying Yan, Yaping Zhang, Xing Huang, Weidang Wu, Changxiao Liu

2020 , 10(9): 1646-1657  

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Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Liying Ma, Haojie Wang, Yinghua You, Chaoya Ma, Yuejiao Liu, Feifei Yang, Yichao Zheng, Hongmin Liu

2020 , 10(9): 1658-1668  

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First small-molecule PROTACs for G proteincoupled receptors: inducing α1A-adrenergic receptor degradation

Zhenzhen Li, Yuxing Lin, Hui Song, Xiaojun Qin, Zhongxia Yu, Zheng Zhang, Gaopan Dong, Xiang Li, Xiaodong Shi, Lupei Du, Wei Zhao, Minyong Li

2020 , 10(9): 1669-1679  

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Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum

Kun Zhang, Yu Zhao, Zheng Zhang, Mengyao Zhang, Xiaodong Wu, Huijie Bian, Ping Zhu, Zhinan Chen

2020 , 10(9): 1680-1693  

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Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics

Chongjin Zhong, Chao Jiang, Suiying Ni, Qizhi Wang, Lingge Cheng, Huan Wang, Qixiang Zhang, Wenyue Liu, Jingwei Zhang, Jiali Liu, Mulan Wang, Min Jin, Peiqiang Shen, Xuequan Yao, Guangji Wang, Fang Zhou

2020 , 10(9): 1694-1708  

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Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Kena Zhao, Tao Guo, Caifen Wang, Yong Zhou, Ting Xiong, Li Wu, Xue Li, Priyanka Mittal, Senlin Shi, Ruxandra Gref, Jiwen Zhang

2020 , 10(9): 1709-1718  

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Computed tomography and photoacoustic imaging guided photodynamic therapy against breast cancer based on mesoporous platinum with insitu oxygen generation ability

Lingyan Zhang, Mifang Li, Quan Zhou, Meng Dang, Yuxia Tang, Shouju Wang, Jijun Fu, Zhaogang Teng, Guangming Lu

2020 , 10(9): 1719-1729  

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Remote loading paclitaxel-edoxorubicin prodrug into liposomes for cancer combination therapy

Jiang Yu, Yingli Wang, Shuang Zhou, Jinbo Li, Jiamei Wang, Dongxu Chi, Xue Wang, Guimei Lin, Zhonggui He, Yongjun Wang

2020 , 10(9): 1730-1740  

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A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy

Xinyu Hou, Chenting Shou, Muye He, Jiajun Xu, Yi Cheng, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen, Feng Gao

2020 , 10(9): 1741-1753  

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Inhibition of post-trabeculectomy fibrosis via topically instilled antisense oligonucleotide complexes co-loaded with fluorouracil

Kuan Jiang, Junyi Chen, Lingyu Tai, Chang Liu, Xishan Chen, Gang Wei, Weiyue Lu, Weisan Pan

2020 , 10(9): 1754-1768  

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Functional nano-vector boost antiatherosclerosis efficacy of berberine in Apoe(-/-) mice

Xiaolei Ma, Tingting Zhang, Zhigang Luo, Xiaolin Li, Miao Lin, Rui Li, Peng Du, Xiaoyou Yu, Chen Ma, Pengju Yan, Jin Su, Lulu Wang, Yuhuan Li, Jiandong Jiang

2020 , 10(9): 1769-1783  

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Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination

Xuehao Tian, Penglong Wang, Tong Li, Xuemei Huang, Wenbo Guo, Yuqin Yang, Mengmeng Yan, Hao Zhang, Desheng Cai, Xiaohui Jia, Feifei Li, Bing Xu, Tao Ma, Cong Yan, Haimin Lei

2020 , 10(9): 1784-1795  

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