Online Submission

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Acta Pharmaceutica Sinica B
2021 Vol. 11 No. 5, 2021-05-25
Reviews
Original articles
Short communication
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Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development
Seyed Hossein Kiaie, Mohammad Javad Sanaei, Masoud Heshmati, Zahra Asadzadeh, Iman Azimi, Saleh Hadidi, Reza Jafari, Behzad Baradaran
2021 , 11(5): 1083-1097
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Energy metabolism disorders and potential therapeutic drugs in heart failure
Yanan He, Wei Huang, Chen Zhang, Lumeng Chen, Runchun Xu, Nan Li, Fang Wang, Li Han, Ming Yang, Dingkun Zhang
2021 , 11(5): 1098-1116
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Regulatory control of the Na—Cl co-transporter NCC and its therapeutic potential for hypertension
Nur Farah Meor Azlan, Maarten P. Koeners, Jinwei Zhang
2021 , 11(5): 1117-1128
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CAR-T cells: Early successes in blood cancer and challenges in solid tumors
Hassan Dana, Ghanbar Mahmoodi Chalbatani, Seyed Amir Jalali, Hamid Reza Mirzaei, Stephan A. Grupp, Eloah Rabello Suarez, Catarina Rapôso, Thomas J. Webster
2021 , 11(5): 1129-1147
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New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors
Xu Hu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu, Keguang Cheng, Huiming Hua, Dahong Li
2021 , 11(5): 1148-1157
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Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies
Qin Wang, Xianyan Qin, Jiyu Fang, Xun Sun
2021 , 11(5): 1158-1174
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Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications
Peng Gao, Xin Chang, Dagan Zhang, Yafei Cai, Gen Chen, Hao Wang, Tianfu Wang
2021 , 11(5): 1175-1199
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Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice
Yuyu Zhu, Ning Wan, Xinni Shan, Guoliang Deng, Qiang Xu, Hui Ye, Yang Sun
2021 , 11(5): 1200-1212
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Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment
Junmei Shangy, Shurong May, Caixia Zang, Xiuqi Bao, Yan Wang, Dan Zhang
2021 , 11(5): 1213-1226
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Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma
Shouyue Zhang, Jin Zhang, Yang An, Xiaoxi Zeng, Ziyi Qin, Yuqian Zhao, Heng Xu, Bo Liu
2021 , 11(5): 1227-1245
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Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma
Zhaoming Lu, Yandan Ren, Li Yang, Ang Jia, Yi Hu, Yu Zhao, Wuduo Zhao, Bin Yu, Wen Zhao, Jianying Zhang, Guiqin Hou
2021 , 11(5): 1246-1260
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SMYD3-PARP16 axis accelerates unfolded protein response and mediates neointima formation
Fen Long, Di Yang, Jinghua Wang, Qing Wang, Ting Ni, Gang Wei, Yizhun Zhu, Xinhua Liu
2021 , 11(5): 1261-1273
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Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis
Zhiyao Xu, Zhuha Zhou, Jing Zhang, Feichao Xuan, Mengjing Fan, Difan Zhou, Zhenyu Liuyang, Ximei Ma, Yiyang Hong, Yihong Wang, Sherven Sharma, Qinghua Dong, Guanyu Wang
2021 , 11(5): 1274-1285
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The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy
Zhenzhen Li, Zhen Guo, Rui Lan, Sidong Cai, Zhirong Lin, Jingyan Li, Junjian Wang, Zhuoming Li, Peiqing Liu
2021 , 11(5): 1286-1299
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Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo
Guoshun Luo, Zhenbang Li, Xin Lin, Xinyu Li, Yu Chen, Kun Xi, Maoxu Xiao, Hanlin Wei, Lizhe Zhu, Hua Xiang
2021 , 11(5): 1300-1314
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Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation
Liang Jiang, Yuting Wang, Qian Li, Zhengchao Tu, Sihua Zhu, Sanfang Tu, Zhang Zhang, Ke Ding, Xiaoyun Lu
2021 , 11(5): 1315-1328
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Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation
Airong Liy, Chenglin Liangy, Lihua Xu, Yiyang Wang, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi
2021 , 11(5): 1329-1340
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Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment
Naveed Ullah Khan, Jiang Ni, Xiufeng Ju, Tongtong Miao, Haiyan Chen, Liang Han
2021 , 11(5): 1341-1354
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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
Shaoyong Lu, Yingyi Chen, Jiacheng Wei, Mingzhu Zhao, Duan Ni, Xinheng He, Jian Zhang
2021 , 11(5): 1355-1361
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- The 1st International Symposium on Autophagy-Biology and Diseases
- Targeting AMPK: Basic Research and Drug Discovery——1st Beijing International Conference November 5th-7th, 2014 Beijing, China-2nd round
- Targeting AMPK: Basic Research and Drug Discovery -- 1st Beijing International Conference November 5th-7th, 2014 Beijing, China
- Application of near infrared spectroscopy to the analysis and fast quality assessment of traditional Chinese medicinal products
- Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry
- Smart polymers for the controlled delivery of drugs – a concise overview