Acta Pharmaceutica Sinica B


2021 Vol. 11 No. 6, 2021-06-25

Editorials

Celebratory message from the Editor-in-Chief on the 10th anniversary of APSB

Jian-dong Jiang

2021 , 11(6): 1363-1363  

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A message from the Co-Editor-in-Chief

Xinxin Ding

2021 , 11(6): 1364-1364  

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Reviews

Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment

Qin Xie, Jian Ding, Yi Chen

2021 , 11(6): 1365-1378  

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A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

Haiyu Xu, Yanqiong Zhang, Ping Wang, Junhong Zhang, Hong Chen, Luoqi Zhang, Xia Du, Chunhui Zhao, Dan Wu, Feng Liu, Hongjun Yang, Changxiao Liu

2021 , 11(6): 1379-1399  

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The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment

Hong Zhang, Liwu Fu

2021 , 11(6): 1400-1411  

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The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Yani Liu, Zongtao Liu, KeWei Wang

2021 , 11(6): 1412-1433  

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Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles

Xiaoxiao Yang, Wen Lu, Christopher P. Hopper, Bowen Ke, Binghe Wang

2021 , 11(6): 1434-1445  

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The disruption of protein-protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

Michael A. Serwetnyk, Brian S.J. Blagg

2021 , 11(6): 1446-1468  

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Insight into chemical basis of traditional Chinese medicine based on the state-of-the-art techniques of liquid chromatography-mass spectrometry

Yang Yu, Changliang Yao, De-an Guo

2021 , 11(6): 1469-1492  

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Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

Qian Hu, Christopher J. Lyon, Jesse K. Fletcher, Wenfu Tang, Meihua Wan, Tony Y. Hu

2021 , 11(6): 1493-1512  

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Original articles

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

Ying Liu, Zan Song, Yajie Liu, Xubin Ma, Wang Wang, Yu Ke, Yichao Xu, Dequan Yu, Hongmin Liu

2021 , 11(6): 1513-1525  

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Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China

Zhiqiang Wang, Zhibo Zhang, Yong Li, Li Sun, Dezhen Peng, Danyu Du, Xian Zhang, Luwei Han, Liwen Zhao, Ligong Lu, Hongzhi Du, Shengtao Yuan, Meixiao Zhan

2021 , 11(6): 1526-1540  

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Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

Lili Ding, Qiaoling Yang, Eryun Zhang, Yangmeng Wang, Siming Sun, Yingbo Yang, Tong Tian, Zhengcai Ju, Linshan Jiang, Xunjiang Wang, Zhengtao Wang, Wendong Huang, Li Yang

2021 , 11(6): 1541-1554  

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Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

Quanjie Li, Dongrong Yi, Xiaobo Lei, Jianyuan Zhao, Yongxin Zhang, Xiangling Cui, Xia Xiao, Tao Jiao, Xiaojing Dong, Xuesen Zhao, Hui Zeng, Chen Liang, Lili Ren, Fei Guo, Xiaoyu Li, Jianwei Wang, Shan Cen

2021 , 11(6): 1555-1567  

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Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide (GLP-1) secretion function of the mouse intestine

Ying Wang, Jiaojiao Zhang, Xinyu Cao, Yaya Guan, Shuang Shen, Genshen Zhong, Xiwen Xiong, Yanhong Xu, Xiaoying Zhang, Hui Wang, Jianping Ye

2021 , 11(6): 1568-1577  

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LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase

Jie Zou, Xiaoyun Zhu, Dejuan Xiang, Yanqiu Zhang, Jie Li, Zhigui Su, Lingyi Kong, Hao Zhang

2021 , 11(6): 1578-1591  

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HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial-mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation

Wei Tian, Jiatong Li, Zhuo Wang, Tong Zhang, Ying Han, Yanyan Liu, Wenfeng Chu, Yu Liu, Baofeng Yang

2021 , 11(6): 1592-1606  

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Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment

Jiashu Xie, Zhengqiang Wang

2021 , 11(6): 1607-1616  

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Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Shipeng He, Junhui Ma, Yuxin Fang, Ying Liu, Shanchao Wu, Guoqiang Dong, Wei Wang, Chunquan Sheng

2021 , 11(6): 1617-1628  

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From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz, Andreas Koeberle

2021 , 11(6): 1629-1647  

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New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity

Lihua Su, Xintian Zhang, Yunbao Ma, Changan Geng, Xiaoyan Huang, Jing Hu, Tianze Li, Shuang Tang, Cheng Shen, Zhen Gao, Xuemei Zhang, Ji-Jun Chen

2021 , 11(6): 1648-1666  

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Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats

David Dahlgren, Tobias Olander, Markus Sjöblom, Mikael Hedeland, Hans Lennernäs

2021 , 11(6): 1667-1675  

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Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

Xiaojun Song, Jianming Lv, Zhiqin Cao, Huiyun Huang, Guodong Chen, Takayoshi Awakawa, Dan Hu, Hao Gao, Ikuro Abe, Xinsheng Yao

2021 , 11(6): 1676-1685  

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Short communication

Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

Zhen Chen, Wakana Mori, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Tomoteru Yamasaki, Atsuto Hiraishi, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang

2021 , 11(6): 1686-1695  

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