Acta Pharmaceutica Sinica B


2021 Vol. 11 No. 7, 2021-07-25

Reviews

3D organoids derived from the small intestine:An emerging tool for drug transport research

Yuanjin Zhang, Shengbo Huang, Weiguo Zhong, Wenxia Chen, Bingyi Yao, Xin Wang

2021 , 11(7): 1697-1707  

Abstract ()     Html (0)    PDF ()

Natural compounds modulate the autophagy with potential implication of stroke

Anil Ahsan, Mengru Liu, Yanrong Zheng, Wenping Yan, Ling Pan, Yue Li, Shijia Ma, Xingxian Zhang, Ming Cao, Zhanxun Wu, Weiwei Hu, Zhong Chen, Xiangnan Zhang

2021 , 11(7): 1708-1720  

Abstract ()     Html (0)    PDF ()

Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy:Challenges and prospects

Javad Masoumi, Abdollah Jafarzadeh, Jalal Abdolalizadeh, Haroon Khan, Jeandet Philippe, Hamed Mirzaei, Hamid Reza Mirzaei

2021 , 11(7): 1721-1739  

Abstract ()     Html (0)    PDF ()

The phytochemical, biological, and medicinal attributes of phytoecdysteroids:An updated review

Niranjan Das, Siddhartha Kumar Mishra, Anusha Bishayee, Eunüs S. Ali, Anupam Bishayee

2021 , 11(7): 1740-1766  

Abstract ()     Html (0)    PDF ()

Recent advances in nanomedicines for the treatment of ischemic stroke

Chao Li, Tao Sun, Chen Jiang

2021 , 11(7): 1767-1788  

Abstract ()     Html (0)    PDF ()

The influence of the gut microbiota on the bioavailability of oral drugs

Xintong Zhang, Ying Han, Wei Huang, Mingji Jin, Zhonggao Gao

2021 , 11(7): 1789-1812  

Abstract ()     Html (0)    PDF ()

Ginsenosides in Panax genus and their biosynthesis

Maoqi Hou, Rufeng Wang, Shujuan Zhao, Zhengtao Wang

2021 , 11(7): 1813-1834  

Abstract ()     Html (0)    PDF ()

Original articles

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei

2021 , 11(7): 1835-1852  

Abstract ()     Html (0)    PDF ()

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

Yi Qian, Meimei Zhao, Qinghua Han, Jingkang Wang, Lixi Liao, Heng Yang, Dan Liu, Pengfei Tu, Hong Liang, Kewu Zeng

2021 , 11(7): 1853-1866  

Abstract ()     Html (0)    PDF ()

A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke

Chenglong Gao, Yazhou Xu, Zhuangzhuang Liang, Yunjie Wang, Qinghong Shang, Shengbin Zhang, Cunfang Wang, Mingmin Ni, Dalei Wu, Zhangjian Huang, Tao Pang

2021 , 11(7): 1867-1884  

Abstract ()     Html (0)    PDF ()

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in-vitro and in-vivo

Xu Wu, Chun Yin, Jiang Ma, Stella Chai, Chunyuan Zhang, Sheng Yao, Onat Kadioglu, Thomas Efferth, Yang Ye, Kenneth Kin-Wah To, Ge Lin

2021 , 11(7): 1885-1902  

Abstract ()     Html (0)    PDF ()

Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models

Ziru Yu, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

2021 , 11(7): 1903-1913  

Abstract ()     Html (0)    PDF ()

Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

Qingfeng Yu, Chengjie Wu, Yeda Chen, Bingsheng Li, Ruixiao Wang, Ru Huang, Xuechun Li, Di Gu, Xiaolong Wang, Xiaolu Duan, Shujue Li, Yang Liu, Wenqi Wu, Martin Hennenberg, Guohua Zeng

2021 , 11(7): 1914-1930  

Abstract ()     Html (0)    PDF ()

AncPhore:A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases

Qingqing Dai, Yuhang Yan, Xiangli Ning, Gen Li, Junlin Yu, Ji Deng, Lingling Yang, Guo-Bo Li

2021 , 11(7): 1931-1946  

Abstract ()     Html (0)    PDF ()

Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu

2021 , 11(7): 1947-1964  

Abstract ()     Html (0)    PDF ()

Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy

Ziyan Zhang, Qiaojuan Liu, Jizhou Tan, Xiaoxia Zhan, Ting Liu, Yuting Wang, Gen Lu, Minhao Wu, Yuanqing Zhang

2021 , 11(7): 1965-1977  

Abstract ()     Html (0)    PDF ()

Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence

Yingying Zhang, Tiange Wang, Yu Tian, Chaonan Zhang, Kun Ge, Jinchao Zhang, Jin Chang, Hanjie Wang

2021 , 11(7): 1978-1992  

Abstract ()     Html (0)    PDF ()

The cellular immunotherapy of integrated photothermal anti-oxidation Pd-Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis

Chuping Zheng, Aiping Wu, Xinyun Zhai, Hong Ji, Zhikang Chen, Xu Chen, Xiyong Yu

2021 , 11(7): 1993-2003  

Abstract ()     Html (0)    PDF ()

Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy

Ling Yu, Zhenjie Wang, Zhuomao Mo, Binhua Zou, Yuanyuan Yang, Rui Sun, Wen Ma, Meng Yu, Shijun Zhang, Zhiqiang Yu

2021 , 11(7): 2004-2015  

Abstract ()     Html (0)    PDF ()

In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organic framework nanoparticles

Lin Hou, Yanlong Liu, Wei Liu, Mervat Balash, Hongling Zhang, Yi Zhang, Huijuan Zhang, Zhenzhong Zhang

2021 , 11(7): 2016-2030  

Abstract ()     Html (0)    PDF ()

Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

Lulu Pang, Siqing Zhu, Jinqiu Ma, Lin Zhu, Yijing Liu, Ge Ou, Ruiteng Li, Yaxin Wang, Yi Liang, Xu Jin, Lina Du, Yiguang Jin

2021 , 11(7): 2031-2047  

Abstract ()     Html (0)    PDF ()

Pure redox-sensitive paclitaxel-maleimide prodrug nanoparticles:Endogenous albumin-induced size switching and improved antitumor efficiency

Xinyu Lou, Dong Zhang, Hao Ling, Zhonggui He, Jin Sun, Mengchi Sun, Dongchun Liu

2021 , 11(7): 2048-2058  

Abstract ()     Html (0)    PDF ()

Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

Bozhao Li, Jingyan Wei, Chunzhi Di, Zefang Lu, Feilong Qi, Yinlong Zhang, Wei Sun Leong, Lele Li, Guangjun Nie, Suping Li

2021 , 11(7): 2059-2069  

Abstract ()     Html (0)    PDF ()

Enzyme-instructed hybrid nanogel/nanofiber oligopeptide hydrogel for localized protein delivery

Tianyue Jiang, Yudi Ma, Xiao Xu, Qingchun Ji, Mingxing Feng, Cheng Cheng, Yang Feng, Bingfang He, Ran Mo

2021 , 11(7): 2070-2079  

Abstract ()     Html (0)    PDF ()

The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study

Zhitao Niu, Fei Zhu, Yajuan Fan, Chao Li, Benhou Zhang, Shuying Zhu, Zhenyu Hou, Mengting Wang, Jiapeng Yang, Qingyun Xue, Wei Liu, Xiaoyu Ding

2021 , 11(7): 2080-2092  

Abstract ()     Html (0)    PDF ()