Acta Pharmaceutica Sinica B


2021 Vol. 11 No. 9, 2021-09-30

Editor Profiles

Editor Profiles: Guest Editors of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”

2021 , 11(9): 2605-2605  

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Editorial

Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”

Jianfeng Cai, Lulu Wei

2021 , 11(9): 2606-2608  

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Review

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Liming Lin, Jiaying Chi, Yilang Yan, Rui Luo, Xiaoqian Feng, Yuwei Zheng, Dongyi Xian, Xin Li, Guilan Quan, Daojun Liu, Chuanbin Wu, Chao Lu, Xin Pan

2021 , 11(9): 2609-2644  

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Original articles

Peptidomimetic-based antibody surrogate for HER2

Mengmeng Zheng, Chunpu Li, Mi Zhou, Ru Jia, Fengyu She, Lulu Wei, Feng Cheng, Qi Li, Jianfeng Cai, Yan Wang

2021 , 11(9): 2645-2654  

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Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

Xiang Li, Neelakshi Gohain, Si Chen, Yinghua Li, Xiaoyuan Zhao, Bo Li, William D. Tolbert, Wangxiao He, Marzena Pazgier, Honggang Hu, Wuyuan Lu

2021 , 11(9): 2655-2669  

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Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRASG12C

Cuicui Li, Ni Zhao, Luyan An, Zhen Dai, Xiaoyi Chen, Fan Yang, Qidong You, Bin Di, Chi Hu, Lili Xu

2021 , 11(9): 2670-2684  

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A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity

Jinqin Chen, Xinhong Liu, Shuo Yu, Jia Liu, Rongfang Chen, Yunxiao Zhang, Ling Jiang, Qiuyun Dai

2021 , 11(9): 2685-2693  

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An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

Mirja Harms, Monica M. W. Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H. Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch

2021 , 11(9): 2694-2708  

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Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang

2021 , 11(9): 2709-2718  

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Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway

Xiaoxia Yang, Pengfei Shang, Bingfang Yu, Qiuyang Jin, Jing Liao, Lei Wang, Jianbo Ji, Xiuli Guo

2021 , 11(9): 2819-2834  

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Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway

Yumiao Zhao, Jiaxin Sun, Yin Li, Xiuman Zhou, Wenjie Zhai, Yahong Wu, Guanyu Chen, Shanshan Gou, Xinghua Sui, Wenshan Zhao, Lu Qiu, Yongjie Yao, Yixuan Sun, Chunxia Chen, Yuanming Qi, Yanfeng Gao

2021 , 11(9): 2835-2849  

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Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2

Haiyan Yan, Jing Sun, Kun Wang, Huiqiang Wang, Shuo Wu, Linlin Bao, Weiqing He, Dong Wang, Airu Zhu, Tian Zhang, Rongmei Gao, Biao Dong, Jianrui Li, Lu Yang, Ming Zhong, Qi Lv, Feifei Qin, Zhen Zhuang, Xiaofang Huang, Xinyi Yang, Yuhuan Li, Yongsheng Che, Jiandong Jiang

2021 , 11(9): 2850-2858  

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Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota-gut-brain axis

Zhe Zhao, Fangyuan Li, Jingwen Ning, Ran Peng, Junmei Shang, Hui Liu, Meiyu Shang, Xiu-Qi Bao, Dan Zhang

2021 , 11(9): 2859-2879  

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Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

Qi Lv, Yao Xing, Jian Liu, Dong Dong, Yue Liu, Hongzhi Qiao, Yinan Zhang, Lihong Hu

2021 , 11(9): 2880-2899  

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Design, synthesis, and biological evaluation of multiple targeting antimalarials

Yiqing Yang, Tongke Tang, Xiaolu Li, Thomas Michel, Liqin Ling, Zhenghui Huang, Maruthi Mulaka, Yue Wu, Hongying Gao, Liguo Wang, Jing Zhou, Brigitte Meunier, Hangjun Ke, Lubin Jiang, Yu Rao

2021 , 11(9): 2900-2913  

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Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks

Xiaojin Chen, Tao Guo, Kaikai Zhang, Jiacai Chen, Caifen Wang, Xiaohong Ren, Qin Wang, Yingchao Yang, Chongjing Liu, Wen Tan, Shuangying Gui, Li Wu, Jiwen Zhang

2021 , 11(9): 2914-2923  

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Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

Wenqi Yu, Ruyi Lin, Xueqin He, Xiaotong Yang, Huilin Zhang, Chuan Hu, Rui Liu, Yuan Huang, Yi Qin, Huile Gao

2021 , 11(9): 2924-2936  

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Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment

Xiaoyu Ning, Christian Wiraja, Wan Ting Sharon Chew, Chen Fan, Chenjie Xu

2021 , 11(9): 2937-2944  

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Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues

Ke Ma, Yuting Zhang, Cui Guo, Yanlong Yang, Junjie Han, Bo Yu, Wenbing Yin, Hongwei Liu

2021 , 11(9): 2945-2956  

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Short communication

Facile synthesis of insulin fusion derivatives through sortase A ligation

Maria M. Disotuar, Jake A. Smith, Jinze Li, Steve Alam, Nai-Pin Lin, Danny Hung-Chieh Chou

2021 , 11(9): 2719-2725  

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Reviews

Integrins as attractive targets for cancer therapeutics

Meng Li, Ying Wang, Mengwei Li, Xuezhen Wu, Sarra Setrerrahmane, Hanmei Xu

2021 , 11(9): 2726-2737  

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Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

Kailin Li, Jieqiong You, Qian Wu, Wen Meng, Qiaojun He, Bo Yang, Chengliang Zhu, Ji Cao

2021 , 11(9): 2738-2748  

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Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Guoyi Tang, Sha Li, Cheng Zhang, Haiyong Chen, Ning Wang, Yibin Feng

2021 , 11(9): 2749-2767  

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Gasdermin D in pyroptosis

Brandon E. Burdette, Ashley N. Esparza, Hua Zhu, Shanzhi Wang

2021 , 11(9): 2768-2782  

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The biology, function, and applications of exosomes in cancer

Jinyi Liu, Liwen Ren, Sha Li, Wan Li, Xiangjin Zheng, Yihui Yang, Weiqi Fu, Jie Yi, Jinhua Wang, Guanhua Du

2021 , 11(9): 2783-2797  

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Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies

Peng Liu, Caifang Gao, Hongguo Chen, Chi Teng Vong, Xu Wu, Xudong Tang, Shengpeng Wang, Yitao Wang

2021 , 11(9): 2798-2818  

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