Online Submission
- 2021 Vol. 11 No. 10
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Acta Pharmaceutica Sinica B
2021 Vol. 11 No. 10, 2021-10-25
Reviews
Tools
Original articles
Commentary
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Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development
Yuli Wang, Xingyan Zhang, Yuyan Wang, Wenjing Zhao, Huling Li, Lixing Zhang, Xinping Li, Tiejun Zhang, Hongbing Zhang, He Huang, Changxiao Liu
2021 , 11(10): 2957-2972
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CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics
Jian Lu, Jie Liu, Yuanqing Guo, Yuanjin Zhang, Yeye Xu, Xin Wang
2021 , 11(10): 2973-2982
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Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy
Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou
2021 , 11(10): 2983-2994
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Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases
Arun Upadhyay
2021 , 11(10): 2995-3014
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Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease
Kai Zhang, Shiou Zhu, Jiamei Li, Tingting Jiang, Lu Feng, Junping Pei, Guan Wang, Liang Ouyang, Bo Liu
2021 , 11(10): 3015-3034
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Recent developments in the medicinal chemistry of single boron atom-containing compounds
Shu Song, Ping Gao, Lin Sun, Dongwei Kang, Jacob Kongsted, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu
2021 , 11(10): 3035-3059
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Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design
Qi Qiao, Xiong Liu, Ting Yang, Kexin Cui, Li Kong, Conglian Yang, Zhiping Zhang
2021 , 11(10): 3060-3091
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MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction
Le Zhang, Lei Zhang, Yue Guo, Ming Xiao, Lu Feng, Chengcan Yang, Guan Wang, Liang Ouyang
2021 , 11(10): 3092-3104
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TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target
Shanshan Liu, Xiaoxi Lv, Xupeng Wei, Chang Liu, Qiao Li, Jiali Min, Fang Hua, Xiaowei Zhang, Ke Li, Pingping Li, Yang Xiao, Zhuowei Hu, Bing Cui
2021 , 11(10): 3105-3119
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PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma
Min Luo, Yuhui Xia, Fang Wang, Hong Zhang, Danting Su, Chaoyue Su, Chuan Yang, Shaocong Wu, Sainan An, Suxia Lin, Liwu Fu
2021 , 11(10): 3120-3133
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Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR
Xiaojia Liu, Mingxiao Yin, Jingwen Dong, Genxiang Mao, Wenjian Min, Zean Kuang, Peng Yang, Lu Liu, Na Zhang, Hongbin Deng
2021 , 11(10): 3134-3149
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3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing
Lina Xu, Lianhong Yin, Yan Qi, Xuemei Tan, Meng Gao, Jinyong Peng
2021 , 11(10): 3150-3164
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Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment
Jianxiang Chen, Yiting Qiao, Guo Chen, Cunjie Chang, Heng Dong, Bo Tang, Xiawei Cheng, Xiufeng Liu, Zichun Hua
2021 , 11(10): 3165-3177
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Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218
Po Hu, Hui Li, Wenzhuo Sun, Hongzheng Wang, Xiaoxuan Yu, Yingjie Qing, Zhanyu Wang, Mengyuan Zhu, Jingyan Xu, Qinglong Guo, Hui Hui
2021 , 11(10): 3178-3192
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Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy
Jing Zhu, Meng Xin, Congcong Xu, Yuan He, Wannian Zhang, Zhibin Wang, Chunlin Zhuang
2021 , 11(10): 3193-3205
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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
Tian Lu, Yong Li, Wenchao Lu, TWGM Spitters, Xueyu Fang, Jun Wang, Simian Cai, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou, Christopher L. Antos, Cheng Luo
2021 , 11(10): 3206-3219
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Bioresponsive micro-to-nano albumin-based systems for targeted drug delivery against complex fungal infections
Liting Cheng, Miao-Miao Niu, Tong Yan, Zhongyi Ma, Kexin Huang, Ling Yang, Xin Zhong, Chong Li
2021 , 11(10): 3220-3230
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Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy
Yu Liang, Li Zhang, Chao Peng, Shiyu Zhang, Siwen Chen, Xin Qian, Wanxian Luo, Qing Dan, Yongyan Ren, Yingjia Li, Bingxia Zhao
2021 , 11(10): 3231-3243
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Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy
Hao Ren, Jiahui Yong, Qingqing Yang, Zhen Yang, Zhangya Liu, Yan Xu, Hao Wang, Xing Jiang, Wenjun Miao, Xueming Li
2021 , 11(10): 3244-3261
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Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy
Dan Li, Yingli Wang, Chang Li, Qiu Wang, Bingjun Sun, Haotian Zhang, Zhonggui He, Jin Sun
2021 , 11(10): 3262-3271
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Cytosolic delivery of the immunological adjuvant Poly I: C and cytotoxic drug crystals via a carrier-free strategy significantly amplifies immune response
Xiaoqing Du, Yuqi Hou, Jia Huang, Yan Pang, Chenlu Ruan, Wei Wu, Chenjie Xu, Hongwei Zhang, Lifang Yin, Wei He
2021 , 11(10): 3272-3285
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Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence
Xiu Han, Xiang Xu, Ziheng Wu, Zhenghong Wu, Xiaole Qi
2021 , 11(10): 3286-3296
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TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor
Tingting Peng, Yao Huang, Xiaoqian Feng, Chune Zhu, Shi Yin, Xinyi Wang, Xuequn Bai, Xin Pan, Chuanbin Wu
2021 , 11(10): 3297-3309
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Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii
Liuying Mao, Baolong Jin, Lingli Chen, Mei Tian, Rui Ma, Biwei Yin, Haiyan Zhang, Juan Guo, Jinfu Tang, Tong Chen, Changjiangsheng Lai, Guanghong Cui, Luqi Huang
2021 , 11(10): 3310-3321
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Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III
Hao Wang, Bo-Yong Zhang, Ting Gong, Tian-Jiao Chen, Jing-Jing Chen, Jin-Ling Yang, Ping Zhu
2021 , 11(10): 3322-3334
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Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity
Bin Lu, Jianpin Ye
2021 , 11(10): 3335-3336
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- The 1st International Symposium on Autophagy-Biology and Diseases
- Targeting AMPK: Basic Research and Drug Discovery——1st Beijing International Conference November 5th-7th, 2014 Beijing, China-2nd round
- Targeting AMPK: Basic Research and Drug Discovery -- 1st Beijing International Conference November 5th-7th, 2014 Beijing, China
- Application of near infrared spectroscopy to the analysis and fast quality assessment of traditional Chinese medicinal products
- Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry
- Smart polymers for the controlled delivery of drugs – a concise overview
