Acta Pharmaceutica Sinica B


2021 Vol. 11 No. 12, 2021-12-25

Editor Profiles

Editor Profiles: Guest Editors of Special Column on Drug- and Chemical-Induced Liver Injury

2021 , 11(12): 3683-3683  

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Editorial

Editorial of Special Column on Drug- and Chemical-Induced Liver Injury

James Luyendyk, Dafna Groeneveld

2021 , 11(12): 3684-3684  

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Reviews

Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction

Antonio Segovia-Zafra, Daniel E. Di Zeo-Sánchez, Carlos López-Gómez, Zeus Pérez-Valdés, Eduardo García-Fuentes, Raúl J. Andrade, M. Isabel Lucena, Marina Villanueva-Paz

2021 , 11(12): 3685-3726  

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Mechanisms of immune checkpoint inhibitor-mediated liver injury

Layla Shojaie, Myra Ali, Andrea Iorga, Lily Dara

2021 , 11(12): 3727-3739  

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Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding, Anup Ramachandran

2021 , 11(12): 3740-3755  

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Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?

Regina D. Schnegelberger, Anna L. Lang, Gavin E. Arteel, Juliane I. Beier

2021 , 11(12): 3756-3767  

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Environmental exposure as a risk-modifying factor in liver diseases: Knowns and unknowns

Juliane I. Beier, Gavin E. Arteel

2021 , 11(12): 3768-3778  

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SARS-CoV-2 cell entry and targeted antiviral development

Zinuo Chen, Ruikun Du, Jazmin M. Galvan Achi, Lijun Rong, Qinghua Cui

2021 , 11(12): 3879-3888  

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Antibody-drug conjugates: Recent advances in linker chemistry

Zheng Su, Dian Xiao, Fei Xie, Lianqi Liu, Yanming Wang, Shiyong Fan, Xinbo Zhou, Song Li

2021 , 11(12): 3889-3907  

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Strategies to overcome drug resistance using SHP2 inhibitors

Meng Liu, Shan Gao, Reham M. Elhassan, Xuben Hou, Hao Fang

2021 , 11(12): 3908-3924  

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Original articles

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

Gundala Venkata Naveen Kumar, Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey, Lauren Kokai, Erin E. Kershaw, Wen Xie, Christian A. Fernandez

2021 , 11(12): 3779-3790  

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Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y. Akakpo, Lili Ji, Li Yang, Thomas Rülicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding

2021 , 11(12): 3791-3805  

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Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver

Jian Jin, Banrida Wahlang, Monika Thapa, Kimberly Z. Head, Josiah E. Hardesty, Sudhir Srivastava, Michael L. Merchant, Shesh N. Rai, Russell A. Prough, Matthew C. Cave

2021 , 11(12): 3806-3819  

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The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

Yisheng He, Jiang Ma, Xiaoyu Fan, Liang Ding, Xinxin Ding, Qing-Yu Zhang, Ge Lin

2021 , 11(12): 3820-3835  

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Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill

2021 , 11(12): 3836-3846  

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Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1

Daniel Rizzolo, Bo Kong, Rulaiha E. Taylor, Anita Brinker, Michael Goedken, Brian Buckley, Grace L. Guo

2021 , 11(12): 3847-3856  

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Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Payal Rana, Michael D. Aleo, Xuerong Wen, Stephen Kogut

2021 , 11(12): 3857-3868  

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Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington

2021 , 11(12): 3869-3878  

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A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT

Zhihao Fu, Hongchuan Liu, Lan Wang, Chuanfei Yu, Yalan Yang, Meiqing Feng, Junzhi Wang

2021 , 11(12): 3925-3934  

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DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer

Manni Wang, Siyuan Chen, Yuquan Wei, Xiawei Wei

2021 , 11(12): 3935-3949  

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Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo

Linglong Deng, Hannah Petrek, Mei-Juan Tu, Neelu Batra, Ai-Xi Yu, Ai-Ming Yu

2021 , 11(12): 3950-3965  

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Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy

Yancheng Tang, Liming Wang, Tao Yi, Jun Xu, Jigang Wang, Jiang-Jiang Qin, Qilei Chen, Ka-Man Yip, Yihang Pan, Peng Hong, Yingying Lu, Han-Ming Shen, Hu-Biao Chen

2021 , 11(12): 3966-3982  

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A small molecule UPR modulator for diabetes identified by high throughput screening

Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li, Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen-Tran, Sean Joseph, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen

2021 , 11(12): 3983-3993  

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TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner

Huaqing Zheng, Xiaolong Li, Xin Zeng, Chengcui Huang, Mingming Ma, Xiaofei Lv, Yajuan Zhang, Lu Sun, Guanlei Wang, Yanhua Du, Yongyuan Guan

2021 , 11(12): 3994-4007  

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Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

Meijia Qian, Fangjie Yan, Weihua Wang, Jiamin Du, Tao Yuan, Ruilin Wu, Chenxi Zhao, Jiao Wang, Jiabin Lu, Bo Zhang, Nengming Lin, Xin Dong, Xiaoyang Dai, Xiaowu Dong, Bo Yang, Hong Zhu, Qiaojun He

2021 , 11(12): 4008-4019  

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Target-responsive subcellular catabolism analysis for early-stage antibody-drug conjugates screening and assessment

Hua Sang, Jiali Liu, Fang Zhou, Xiaofang Zhang, Jingwei Zhang, Yazhong Liu, Guangji Wang, Hui Ye

2021 , 11(12): 4020-4031  

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A nanocleaner specifically penetrates the blood-brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease

Ting Lei, Zhihang Yang, Xue Xia, Yuxiu Chen, Xiaotong Yang, Rou Xie, Fan Tong, Xiaolin Wang, Huile Gao

2021 , 11(12): 4032-4044  

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Short communication

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1

Na Kong, Xiaying Chen, Jiao Feng, Ting Duan, Shuiping Liu, Xueni Sun, Peng Chen, Ting Pan, Lili Yan, Ting Jin, Yu Xiang, Quan Gao, Chengyong Wen, Weirui Ma, Wencheng Liu, Mingming Zhang, Zuyi Yang, Wengang Wang, Ruonan Zhang, Bi Chen, Tian Xie, Xinbing Sui, Wei Tao

2021 , 11(12): 4045-4054  

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