Abstract: The most common neurodegenerative disease, Alzheimer disease (AD) constitutes the majority of all senile dementia cases. Extending life expectancy contributes to the increased incidence of AD, which is a serious threat to the quality of life of the elderly. The etiology and pathogenesis of AD are not absolutely clear. There are various kinds of hypotheses, such as abnormal phosphorylation of tau proteins, amyloid-beta protein toxicity, gene mutation, degeneration of cholinergic system, neuroinflammation, oxidative stress. Based on the above-mentioned theories, lots of studies of Uncaria Hook have been conducted in Alzheimer disease models. In this paper, we reviewed the latest research of Uncaria Hook on Alzheimer disease models to provide reference for further development of Uncaria Hook's medicinal potential.