李宇璐, 代华年, 马国需, 章文, 吴桐宇, 王云卿, 邹节明, 钟小清, 周艳林, 袁经权, 许旭东, 易蔚. 金樱子根中一个新三萜酸J. 药学学报, 2017,52(3): 425-429. doi: 10.16438/j.0513-4870.2016-1116
引用本文: 李宇璐, 代华年, 马国需, 章文, 吴桐宇, 王云卿, 邹节明, 钟小清, 周艳林, 袁经权, 许旭东, 易蔚. 金樱子根中一个新三萜酸J. 药学学报, 2017,52(3): 425-429. doi: 10.16438/j.0513-4870.2016-1116
LI Yu-lu, DAI Hua-nian, MA Guo-xu, ZHANG Wen, WU Tong-yu, WANG Yun-qing, ZOU Jie-ming, ZHONG Xiao-qing, ZHOU Yan-lin, YUAN Jing-quan, XU Xu-dong, YI Wei. A new triterpenic acid from the roots of Rosa laevigataJ. Acta Pharmaceutica Sinica, 2017,52(3): 425-429. doi: 10.16438/j.0513-4870.2016-1116
Citation: LI Yu-lu, DAI Hua-nian, MA Guo-xu, ZHANG Wen, WU Tong-yu, WANG Yun-qing, ZOU Jie-ming, ZHONG Xiao-qing, ZHOU Yan-lin, YUAN Jing-quan, XU Xu-dong, YI Wei. A new triterpenic acid from the roots of Rosa laevigataJ. Acta Pharmaceutica Sinica, 2017,52(3): 425-429. doi: 10.16438/j.0513-4870.2016-1116

金樱子根中一个新三萜酸

A new triterpenic acid from the roots of Rosa laevigata

  • 摘要: 利用多种色谱分离方法对金樱子根中的化学成分进行分离和纯化,并根据化合物的理化性质和光谱分析进行结构鉴定。从金樱子根的乙酸乙酯及丙酮提取部位中分离得到了5个三萜酸类化学成分,分别鉴定为:19α-OH-3β-E-feruloyl corosolic acid(1)、23-hydroxy-tormentic acid(2)、2α,3β,19α,23-四羟基-齐墩果-12-烯-28-酸(3)、2α,3α,20β-三羟基乌苏烷-13(18)-烯-28-酸(4)和2α,3β,20β-三羟基乌苏烷-13(18)-烯-28-酸(5)。其中,化合物1为新化合物,化合物4、5为首次从蔷薇属植物中分离得到。

     

    Abstract: This study was designed to investigate triterpenoids from the roots of Rosa laevigata Michx. The silica gel column chromatography was used to separate the chemical constituents from the roots of Rosa laevigata Michx. HPLC was used to analyze its purity and chemical constitution. Spectroscopy methods were used to determine their structures. Five constituents were isolated and identified as19α-OH-3β-E-feruloyl corosolic acid (1), 23-hydroxy-tormentic acid (2), 2α, 3β, 19α, 23-tetrahydroxy-12-en-28-oleanolic acid (3), 2α, 3α, 20β-trihydroxyurs-13 (18)-en-28-oic-acid (4), 2α, 3β, 20β-trihydroxyurs-13 (18)-en-28-oic-acid (5). Compound 1 was assigned as a new compound, compounds 4, 5 were obtained from the genus Rosa for the first time.

     

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